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UROLOGY：前列腺特异性膜抗原表达的影像学研究

2018-02-22 MedSci MedSci原创

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前列腺特异性膜抗原由许多肿瘤的内皮细胞表达。本研究的目的是为探索前列腺特异性膜抗原的影像学的基本原理，并探讨在肾细胞癌患者中血管前列腺特异性膜抗原表达所起到的预后作用。

前列腺特异性膜抗原由许多肿瘤的内皮细胞表达。本研究的目的是为探索前列腺特异性膜抗原的影像学的基本原理，并探讨在肾细胞癌患者中血管前列腺特异性膜抗原表达所起到的预后作用。

共有257例肾细胞癌患者纳入研究，中位随访时间超过10年。研究人员采用免疫组化法检测肿瘤血管中前列腺特异性膜抗原表达，并利用TCGA(癌症基因组图谱)数据，研究了透明细胞癌和乳头状肾细胞癌中FOLH1基因(前列腺特异性膜抗原)mRNA的血管表达。

在透明细胞中，内皮前列腺特异性膜抗原蛋白表达高于乳头状和嗜铬细胞癌。在肿瘤血管中，较高的分级和分期、转移和致死的透明细胞癌表现出较高的前列腺特异性膜抗原表达。单变量和多变量分析阳性vs阴性内皮前列腺特异性膜抗原蛋白表达的强度与总体生存率有显着相关性。基于TCGA的分析证实了FOLH1 mRNA血管表达的预后作用。该分析还支持了前列腺特异性膜抗原成像在透明细胞而非乳头状肾细胞癌的作用。

结论
本项研究为肾透明细胞癌患者的前列腺特异性膜抗原靶向成像的进一步发展提供了理论依据，其预后作用还值得进一步研究。

原始出处：
Sophia Spatz.et al.Comprehensive Evaluation of Prostate Specific Membrane Antigen Expression in the Vasculature of Renal Tumors： Implications for Imaging Studies and Prognostic Role.UROLOGY.2018.

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    2018-11-27 gj0731

    #前列腺特异性膜抗原#

    0

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    2018-05-05 jinweidong

    #特异性#

    0

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    2018-02-24 xiaoyeshuang

    #抗原#

    0

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    2018-02-23 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1937599, encodeId=b780193e599fc, content=<a href='/topic/show?id=2f863252123' target=_blank style='color:#2F92EE;'>#前列腺特异性膜抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32521, encryptionId=2f863252123, topicName=前列腺特异性膜抗原)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f76619, createdName=gj0731, createdTime=Tue Nov 27 06:16:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1899199, encodeId=ccf1189919967, content=<a href='/topic/show?id=6f746e94170' target=_blank style='color:#2F92EE;'>#特异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67941, encryptionId=6f746e94170, topicName=特异性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Sat May 05 11:16:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623274, encodeId=ef3c16232e4a9, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Sat Feb 24 12:16:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290163, encodeId=2b9229016397, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Feb 23 08:38:04 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290102, encodeId=cdaa290102f0, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Fri Feb 23 06:36:32 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290015, encodeId=012d290015c5, content=前列腺特异性膜抗原由许多肿瘤的内皮细胞表达.本研究的目的是为探索前列腺特异性膜抗原的影像学的基本原理.并探讨在肾细胞癌患者中血管前列腺特异性膜抗原表达所起到的预后作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Feb 22 22:32:33 CST 2018, time=2018-02-22, status=1, ipAttribution=)]
    2018-02-23 swfzhanggui

    非常好.谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1937599, encodeId=b780193e599fc, content=<a href='/topic/show?id=2f863252123' target=_blank style='color:#2F92EE;'>#前列腺特异性膜抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32521, encryptionId=2f863252123, topicName=前列腺特异性膜抗原)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f76619, createdName=gj0731, createdTime=Tue Nov 27 06:16:00 CST 2018, time=2018-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1899199, encodeId=ccf1189919967, content=<a href='/topic/show?id=6f746e94170' target=_blank style='color:#2F92EE;'>#特异性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67941, encryptionId=6f746e94170, topicName=特异性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc7a157, createdName=jinweidong, createdTime=Sat May 05 11:16:00 CST 2018, time=2018-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623274, encodeId=ef3c16232e4a9, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Sat Feb 24 12:16:00 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290163, encodeId=2b9229016397, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Feb 23 08:38:04 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290102, encodeId=cdaa290102f0, content=非常好.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/21/9461f3b3c9f14e1d844256cdd08f2cf3.jpg, createdBy=a30f1426910, createdName=swfzhanggui, createdTime=Fri Feb 23 06:36:32 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290015, encodeId=012d290015c5, content=前列腺特异性膜抗原由许多肿瘤的内皮细胞表达.本研究的目的是为探索前列腺特异性膜抗原的影像学的基本原理.并探讨在肾细胞癌患者中血管前列腺特异性膜抗原表达所起到的预后作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Thu Feb 22 22:32:33 CST 2018, time=2018-02-22, status=1, ipAttribution=)]
    2018-02-22 有备才能无患

    前列腺特异性膜抗原由许多肿瘤的内皮细胞表达.本研究的目的是为探索前列腺特异性膜抗原的影像学的基本原理.并探讨在肾细胞癌患者中血管前列腺特异性膜抗原表达所起到的预后作用.

    0