CLIN CANCER RES：肝细胞癌免疫微环境特点

2017-12-09 MedSci MedSci原创

肝细胞癌是一种恶性肿瘤，通常由慢性肝脏疾病或肝硬化发展而来。世界范围内肝细胞癌是肿瘤相关死亡的第二大因素。肝细胞癌的主要风险因素包括肝炎肝硬化，酒精性肝疾病和非酒精性脂肪肝。肝细胞癌可能对免疫治疗存在反应。CLIN CANCER RES近期发表了一篇文章，研究肝细胞癌的免疫微环境特点。

肝细胞癌是一种恶性肿瘤，通常由慢性肝脏疾病或肝硬化发展而来。世界范围内肝细胞癌是肿瘤相关死亡的第二大因素。肝细胞癌的主要风险因素包括肝炎肝硬化，酒精性肝疾病和非酒精性脂肪肝。肝细胞癌可能对免疫治疗存在反应。CLIN CANCER RES近期发表了一篇文章，研究肝细胞癌的免疫微环境特点。

作者对29例切除后的肝细胞癌标本的CD8阳性T淋巴细胞，PD-1阳性和LAG-3阳性淋巴细胞，CD163阳性巨噬细胞和肿瘤PD-L1表达进行染色。研究结果表明，肿瘤中CD8表达下降，肿瘤交界处CD163表达降低。29例标本中有24例PD-L1阳性表达，19例肿瘤浸润淋巴细胞LAG-3阳性表达。与肝实质背景相比，肿瘤中PD-L1和LAG-3表达增加。并未发现病毒状态或其他临床病理特征与上述免疫组化标志表达之间存在关系。

文章最后认为，LAG-3和PD-L1，两个与CD8T细胞耐受相关的抑制分子，在大部分肝细胞癌中升高。可以进一步研究LAG-3和PD-L1联合抑制治疗肝细胞癌的可行性。

原始出处：

Mark Yarchoan,Dongmei Xing,et al.Characterization of the Immune Microenvironment in Hepatocellular Carcinoma.CLIN CANCER RES.December 2017 doi:10.1158/1078-0432.CCR-17-0950

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2018-09-19 xjy02

#肝细胞#

20 0
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2018-08-10 qingting

#细胞癌#

29 0
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2017-12-09 蔬菜

好文章.学习了新知识新前沿

37 0
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2017-12-09 1ddf0692m34(暂无匿称)

学习了.涨知识

52 0
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2017-12-09 执着追梦

学习.谢谢分享

47 0
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2017-12-09 Jackie Li

学习

44 0
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2017-12-09 1e11f6a6m77(暂无匿称)

学习学习

48 0

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