J Periodontal Res:虾青素对实验性牙周炎牙槽骨吸收的影响

2018-04-05 MedSci MedSci原创

虾青素是一种具有强抗氧化作用的酮类胡萝卜素。本研究的目的是评估虾青素对大鼠结扎诱导性牙周炎牙槽骨吸收和组织病理学变化的影响。

虾青素是一种具有强抗氧化作用的酮类胡萝卜素。本研究的目的是评估虾青素对大鼠结扎诱导性牙周炎牙槽骨吸收和组织病理学变化的影响。

将Wistar大鼠分成四个实验组:未结扎(C,n = 6);单纯结扎(L,n = 6);结扎+虾青素(虾青素1mg / kg /天,AS1组,n = 8);结扎+虾青素(虾青素5mg / kg /天,AS5组,n = 8)。将丝线结扎放置在下颌第一磨牙的龈缘。实验持续时间11天,之后动物被处死。临床测量牙槽骨水平的变化,并测定免疫组织化学检查,骨钙素,骨形态发生蛋白-2,诱导型一氧化氮合酶,牙槽骨和抗酒石酸酸性磷酸酶阳性破骨细胞,成骨细胞和炎性细胞中Bax和bcl-2水平细胞计数。

结果:L组的牙槽骨吸收最高,L,AS1和AS5组之间的差异也显着(P <.05)。两种剂量的虾青素均可降低酒石酸耐受性酸性磷酸酶阳性+破骨细胞的数量并增加成骨细胞计数(P <0.05)。 L组炎症也高于C组和AS1组(P <0.05),表明虾青素的抗炎作用。尽管诱导型一氧化氮合酶,骨钙素,骨形态发生蛋白-2和bax染色百分率均在AS5组最高,而AS1组bcl-2染色百分率最高,但值接近(P> 0.05)。

结论:在本研究认为虾青素可以通过增加实验性牙周炎模型中的成骨细胞活性并减少破骨细胞活性来减少牙槽骨吸收。

原始出处:

H. Balci Yuce, et al. Investigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitis. Journal of Periodontal Research. 2018 February. doi:10.1111/jre.12497

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    2018-10-12 mei540
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    2019-03-15 feather89
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    2019-03-09 lujian
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    2018-04-07 徐岩
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    2018-04-05 183****7028

    学习

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