Int J Cancer:饮酒和吸烟可增加对侧乳腺癌风险!

2017-05-22 MedSci MedSci原创

饮酒和吸烟是第一原发性乳腺癌的危险因素。临床诊断时,这些信息可能有助于对侧乳腺癌(CBC)的风险预测,同时他们也是潜在地可变因子。WECARE研究是一个对乳腺癌女性进行的以人群为基础的病例对照研究,该研究中有不同期的CBC女性(n = 1521)和对照组(n = 2212),对比了二组间的生存时间及其它因素、患有单侧乳腺癌(UBC)。本研究的研究人员研究了在第一次诊断时和诊断之后,与饮酒史和吸烟史

饮酒和吸烟是第一原发性乳腺癌的危险因素。临床诊断时,这些信息可能有助于对侧乳腺癌(CBC)的风险预测,同时他们也是潜在地可变因子。

WECARE研究是一个对乳腺癌女性进行的以人群为基础的病例对照研究,该研究中有不同期的CBC女性(n = 1521)和对照组(n = 2212),对比了二组间的生存时间及其它因素、患有单侧乳腺癌(UBC)。本研究的研究人员研究了在第一次诊断时和诊断之后,与饮酒史和吸烟史相关的CBC的风险,并使用多变量条件Logistic回归估计相对危险度(rate ratios,RR)和95%置信区间(95%CI)。调整治疗、疾病特征和其他因素。

研究发现了一些证据证明:在第一原发性乳腺癌诊断时CBC风险与目前饮酒和吸烟相关,但风险增加主要发生在同时暴露于两种危险因素中的女性(RR = 1.62,95% CI,1.24-2.11)。诊断后依然同时吸烟和饮酒的女性的CBC风险也升高(RR = 1.54,95% CI,1.18-1.99)。在关于消耗量的详细信息的子集研究中,乳腺癌诊断后平均每天吸烟≥10支也与CBC风险增加相关(RR = 1.50,95% CI,1.08-2.08;P趋势= 0.03)。

在确诊乳腺癌的女性中,当下饮酒和吸烟的信息可能有助于预测CBC的风险。同时饮酒和吸烟的女性可能需要进行针对性的生活方式干预,以改变其患对侧乳腺癌的风险。

原始出处:


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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Mon May 29 21:21:06 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201575, encodeId=f0ab2015e5bd, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue May 23 08:17:48 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201570, encodeId=49902015e0a8, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Tue May 23 07:01:44 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201518, encodeId=05012015181a, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue May 23 06:53:40 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201515, encodeId=421c2015157c, content=确定是共同作用还是单独作用,各自作用又是如何发挥的, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Tue May 23 06:52:38 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-29 海棠胜雪

    学习了,谢谢分享

    0

  5. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Tue May 23 06:52:38 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 doctorJiangchao

    继续学习。

    0

  6. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Tue May 23 06:52:38 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 龙胆草

    学习了,谢谢分享

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Tue May 23 07:01:44 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201518, encodeId=05012015181a, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue May 23 06:53:40 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201515, encodeId=421c2015157c, content=确定是共同作用还是单独作用,各自作用又是如何发挥的, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Tue May 23 06:52:38 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 往日如昨

    学习了谢谢分享

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Tue May 23 07:01:44 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201518, encodeId=05012015181a, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue May 23 06:53:40 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201515, encodeId=421c2015157c, content=确定是共同作用还是单独作用,各自作用又是如何发挥的, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Tue May 23 06:52:38 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 七堇

    烟酒适当少吃,不吃,健康很重要

    0

  9. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Tue May 23 06:52:38 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-05-23 刘煜

    学习了谢谢分享。

    0

  10. 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    2017-05-23 sillywu

    确定是共同作用还是单独作用,各自作用又是如何发挥的

    0