J Clin Periodontol:牙周病与妊娠期糖尿病之间的关联

2018-04-05 MedSci MedSci原创

本研究旨在确定牙周疾病与妊娠期糖尿病(GDM)之间的关联以及该关联对北印度人群妊娠结局的影响。研究共招募了584名妊娠12-14周的孕妇。招募时对其进行牙周检查及75g口服葡萄糖负荷试验。按照DIPSI(妊娠糖尿病研究组印度)指南(≥140mg/ dL)诊断为GDM。血糖正常的女性在妊娠24-28周时重复75g口服葡萄糖负荷试验。所有患者均随访观察妊娠结果。结果显示,在584例初产妇中,184例(

本研究旨在确定牙周疾病与妊娠期糖尿病(GDM)之间的关联以及该关联对北印度人群妊娠结局的影响。

研究共招募了584名妊娠12-14周的孕妇。招募时对其进行牙周检查及75g口服葡萄糖负荷试验。按照DIPSI(妊娠糖尿病研究组印度)指南(≥140mg/ dL)诊断为GDM。血糖正常的女性在妊娠24-28周时重复75g口服葡萄糖负荷试验。所有患者均随访观察妊娠结果。

结果显示,在584例初产妇中,184例(31.5%)患牙龈炎,148例(25.3%)患牙周炎。总体而言,332名(56.8%)孕妇患有牙周病。牙周病与GDM相关,校正后的危险比(aHR)为2.85(95%CI = 1.47-5.53)。先兆子痫的发生与牙周病有关,aHR为2.20(95%CI = 0.86-5.60)。如果初产妇患有牙周病伴GDM,先兆子痫的风险aHR增加18.79(95%CI = 7.45 - 47.40)。

综上所述,该研究显示牙周病与妊娠期糖尿病明显相关,且由于这种相关性而导致先兆子痫的发生风险增加。

原始出处:


Kumar A, Sharma DS, et al., Association between periodontal disease and gestational diabetes mellitus (GDM) - a prospective cohort study. J Clin Periodontol. 2018 Apr 3. doi: 10.1111/jcpe.12902.

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    2018-11-03 feather89
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    2018-04-07 wjcjjian
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