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Oncogene：生物标志物揭示癌症发病原因

2014-10-11 佚名 生物谷

蛋白质CLIP2乳头状甲状腺癌
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近日研究发现，蛋白质CLIP2 的表达了提供一项关于放射是否引起乳头状甲状腺癌信息。通过这一发现科学家们确定了一个诊断癌症的新的生物标志物。他们的发现发表在《致癌基因》杂志上。 科学家们的研究能够证实，CLIP2作为放射标志物在通过放射性碘辐射后基因活性和蛋白表达量同时增加。CLIP2在通过射线照射甲状腺肿瘤后似乎显得特别重要。Martin Selmansberger博士带领的团队研究发现高水

近日研究发现，蛋白质CLIP2 的表达了提供一项关于放射是否引起乳头状甲状腺癌信息。通过这一发现科学家们确定了一个诊断癌症的新的生物标志物。他们的发现发表在《致癌基因》杂志上。

科学家们的研究能够证实，CLIP2作为放射标志物在通过放射性碘辐射后基因活性和蛋白表达量同时增加。CLIP2在通过射线照射甲状腺肿瘤后似乎显得特别重要。Martin Selmansberger博士带领的团队研究发现高水平的CLIP2含量和曾经通过放射治疗乳头状甲状腺瘤的患者之间有一定的关系。“在我们的研究中，我们能够验证在三组不同原因的甲状腺癌患者的研究人群中，辐射相关的CLIP2的蛋白水平表达量的不同。”第一作者Selmansberger说道。

“CLIP2作为辐射标志物，使我们能够区分辐射诱导甲状腺癌和散发甲状腺癌的区别。”研究人员He补充道。在他们的研究中，科学家们开发了一种标准化的方法来确定CLIP2生物标志物的重要性。“这种生物标记的作用是帮助我们得出有关肿瘤发展的机制和评估暴露于高水平辐射后患甲状腺癌的风险的结论。例如，验证辐射事故发生后患甲状腺癌的结果。”He说道。

有关CLIP2能够使甲状腺致癌这一理论至今是未知的。重建的CLIP2调控基因显示CLIP2参与基本的致癌过程，因此会促进肿瘤的恶化。

原始出处：

Selmansberger M1, Feuchtinger A2, Zurnadzhy L3, Michna A1, Kaiser JC4, Abend M5, Brenner A6, Bogdanova T3, Walch A2, Unger K1, Zitzelsberger H1, Hess J1.CLIP2 as radiation biomarker in papillary thyroid carcinoma.Oncogene. 2014 Oct 6. doi: 10.1038/onc.2014.311. [Epub ahead of print]

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    2016-03-22 Gsurgeon

    不错的学习内容

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    2015-09-16 hukaixun

    #标志物#

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    2015-03-15 cy0324

    #Gene#

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    2014-10-13 zsyan

    #Oncogene#

    0

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    2014-10-13 zhu_jun9842

    #生物标志#

    0

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    2014-10-13 zhu_jun9842

    #生物标志#

    0