Neuron:用全脑功能超声成像来展现视觉运动的大脑区域整合

2018-12-17 MedSci MedSci原创

瑞士巴塞尔分子与临床眼科研究所的MaceE等人在Neuron杂志上发表了一篇文章,研究者开发了功能性超声成像技术,可以按照约100μm的分辨率来记录行为发生过程中小鼠的全脑活动。

瑞士巴塞尔分子与临床科研究所的MaceE等人在Neuron杂志上发表了一篇文章,研究者开发了功能性超声成像技术,可以按照约100μm的分辨率来记录行为发生过程中小鼠的全脑活动。

在发生行为时,大量的大脑区域是活跃的。高分辨率的大脑活动图可以识别特定行为中涉及的大脑区域。他们对小鼠进行视动反射测试,这是一种视觉运动行为,可以在水平和垂直方向上稳定凝视。在这个视觉刺激期间,总共检测到87个活跃的大脑区域。使用不能产生水平反射的先天性眼球震颤的遗传小鼠模型,他们发现,其活动区域是正常反射区域的子集。通过阻止对照动物的眼球运动,他们进一步发现,其活动取决于反射运动输出的区域。值得注意的是,所有依赖于反射但与眼球运动无关的活性区域都位于丘脑中。

因此,他们认为,这项工作完成了对涉及视觉运动大脑区域功能模块的整合,并提供了一种实验方法来监测正常和疾病状态下小鼠的全脑活动。

原文出处:

Mace, E., et al., Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration. Neuron, 2018. 100(5): p. 1241-1251.e7.

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    2019-07-23 by2021
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1969312, encodeId=bf5e1969312d1, content=<a href='/topic/show?id=f95a92e973b' target=_blank style='color:#2F92EE;'>#超声成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92797, encryptionId=f95a92e973b, topicName=超声成像)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Thu May 02 11:01:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038001, encodeId=a49d2038001e5, content=<a href='/topic/show?id=e27b438e92b' target=_blank style='color:#2F92EE;'>#大脑区域#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43879, encryptionId=e27b438e92b, topicName=大脑区域)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Sun Nov 03 00:01:00 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1751874, encodeId=cf6c1e51874b0, content=<a href='/topic/show?id=9b6a12e0155' target=_blank style='color:#2F92EE;'>#Neuron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12701, encryptionId=9b6a12e0155, topicName=Neuron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9c736410065, createdName=by2021, createdTime=Tue Jul 23 11:01:00 CST 2019, time=2019-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801634, encodeId=1a99180163494, content=<a href='/topic/show?id=8ea3908e70d' target=_blank style='color:#2F92EE;'>#视觉运动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90877, encryptionId=8ea3908e70d, topicName=视觉运动)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da20314, createdName=lfcmxl, createdTime=Sun Aug 11 07:01:00 CST 2019, time=2019-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442436, encodeId=08ef1442436c3, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Wed Dec 19 13:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481117, encodeId=ab1c148111eaf, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Wed Dec 19 13:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355690, encodeId=11c735569065, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Dec 17 22:45:57 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1969312, encodeId=bf5e1969312d1, content=<a href='/topic/show?id=f95a92e973b' target=_blank style='color:#2F92EE;'>#超声成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92797, encryptionId=f95a92e973b, topicName=超声成像)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Thu May 02 11:01:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038001, encodeId=a49d2038001e5, content=<a href='/topic/show?id=e27b438e92b' target=_blank style='color:#2F92EE;'>#大脑区域#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43879, encryptionId=e27b438e92b, topicName=大脑区域)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Sun Nov 03 00:01:00 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1751874, encodeId=cf6c1e51874b0, content=<a href='/topic/show?id=9b6a12e0155' target=_blank style='color:#2F92EE;'>#Neuron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12701, encryptionId=9b6a12e0155, topicName=Neuron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9c736410065, createdName=by2021, createdTime=Tue Jul 23 11:01:00 CST 2019, time=2019-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801634, encodeId=1a99180163494, content=<a href='/topic/show?id=8ea3908e70d' target=_blank style='color:#2F92EE;'>#视觉运动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90877, encryptionId=8ea3908e70d, topicName=视觉运动)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da20314, createdName=lfcmxl, createdTime=Sun Aug 11 07:01:00 CST 2019, time=2019-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442436, encodeId=08ef1442436c3, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Wed Dec 19 13:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481117, encodeId=ab1c148111eaf, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Wed Dec 19 13:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355690, encodeId=11c735569065, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Dec 17 22:45:57 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
    2018-12-19 zywlvao
  7. [GetPortalCommentsPageByObjectIdResponse(id=1969312, encodeId=bf5e1969312d1, content=<a href='/topic/show?id=f95a92e973b' target=_blank style='color:#2F92EE;'>#超声成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92797, encryptionId=f95a92e973b, topicName=超声成像)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20b5274, createdName=JR19860219, createdTime=Thu May 02 11:01:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038001, encodeId=a49d2038001e5, content=<a href='/topic/show?id=e27b438e92b' target=_blank style='color:#2F92EE;'>#大脑区域#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43879, encryptionId=e27b438e92b, topicName=大脑区域)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Sun Nov 03 00:01:00 CST 2019, time=2019-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1751874, encodeId=cf6c1e51874b0, content=<a href='/topic/show?id=9b6a12e0155' target=_blank style='color:#2F92EE;'>#Neuron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12701, encryptionId=9b6a12e0155, topicName=Neuron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c9c736410065, createdName=by2021, createdTime=Tue Jul 23 11:01:00 CST 2019, time=2019-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801634, encodeId=1a99180163494, content=<a href='/topic/show?id=8ea3908e70d' target=_blank style='color:#2F92EE;'>#视觉运动#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90877, encryptionId=8ea3908e70d, topicName=视觉运动)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da20314, createdName=lfcmxl, createdTime=Sun Aug 11 07:01:00 CST 2019, time=2019-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442436, encodeId=08ef1442436c3, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Wed Dec 19 13:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481117, encodeId=ab1c148111eaf, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Wed Dec 19 13:01:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=355690, encodeId=11c735569065, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Dec 17 22:45:57 CST 2018, time=2018-12-17, status=1, ipAttribution=)]
    2018-12-17 天地飞扬

    了解一下,谢谢分享!

    0