Nanotechnology:通过空气等离子体处理形成掺杂有银纳米颗粒的聚己内酯电纺纳米纤维可有效抗菌

2019-02-06 MedSci MedSci原创

植体易受到细菌感染,可能导致植体松动。减轻这些感染对于植体稳定性和患者健康都很重要。抗菌植体涂层的开发可以减少细菌菌落的存在,降低细菌依赖性植体失效的风险。在这里,我们表明掺杂银纳米粒子(NPs)从静电硝酸银前体的电纺聚己内酯(PCL)纤维有可能降低肺炎链球菌(肺炎链球菌)的流行,同时支持成骨细胞附着和增殖。采用PCL电纺纤维的空气等离子体还原方法制备掺杂银纳米颗粒的纤维。使用扫描电子显微镜(SE

植体易受到细菌感染,可能导致植体松动。减轻这些感染对于植体稳定性和患者健康都很重要。抗菌植体涂层的开发可以减少细菌菌落的存在,降低细菌依赖性植体失效的风险。

在这里,我们表明掺杂银纳米粒子(NPs)从静电硝酸银前体的电纺聚己内酯(PCL)纤维有可能降低肺炎链球菌(肺炎链球菌)的流行,同时支持成骨细胞附着和增殖。采用PCL电纺纤维的空气等离子体还原方法制备掺杂银纳米颗粒的纤维。使用扫描电子显微镜(SEM)和透射电子显微镜(TEM)对纤维进行表征,以定性评估NP分布和纤维直径的定量分析。在暴露24小时后观察到细菌成功抑制。使用Saos-2细胞完成体外测试,并表明即使在含有NP的纤维存在下,负表面电荷也有可能增加细胞活力。

总之,该研究描述了一种生产可生物再吸收的植体涂层的新方法,该涂层能够减少植体表面周围的细菌感染,同时保持与宿主的生物相容性。

原始出处:

Binkley DM, Lee BEJ, et al., Fabrication of polycaprolactone electrospun nanofibers doped with silver nanoparticles formed by air plasma treatment. Nanotechnology. 2019 Feb 4. doi: 10.1088/1361-6528/ab0444. 

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    2019-06-21 shock_melon
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  5. 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  6. 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  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 07 12:09:32 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360088, encodeId=b32b36008810, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Thu Feb 07 05:47:32 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360046, encodeId=630a360046a2, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Feb 06 10:42:33 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360041, encodeId=b10c3600419c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Feb 06 09:33:27 CST 2019, time=2019-02-06, status=1, ipAttribution=)]
    2019-02-07 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 07 12:09:32 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360088, encodeId=b32b36008810, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Thu Feb 07 05:47:32 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360046, encodeId=630a360046a2, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Feb 06 10:42:33 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360041, encodeId=b10c3600419c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Feb 06 09:33:27 CST 2019, time=2019-02-06, status=1, ipAttribution=)]
    2019-02-07 yjs木玉

    好好好好好好

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Feb 06 10:42:33 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360041, encodeId=b10c3600419c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Feb 06 09:33:27 CST 2019, time=2019-02-06, status=1, ipAttribution=)]
    2019-02-06 一天没事干

    很好的学习机会

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 07 12:09:32 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360088, encodeId=b32b36008810, content=好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Thu Feb 07 05:47:32 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360046, encodeId=630a360046a2, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Wed Feb 06 10:42:33 CST 2019, time=2019-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360041, encodeId=b10c3600419c, content=学习了长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Feb 06 09:33:27 CST 2019, time=2019-02-06, status=1, ipAttribution=)]
    2019-02-06 1ddf0692m34(暂无匿称)

    学习了长知识

    0