J Periodontal Res:使用羊上颌窦模型研究移植材料

2018-03-31 MedSci MedSci原创

这项初步研究的目的是研究表面形态,并评估两种脱蛋白牛骨移植材料在大型动物模型的鼻窦移植术后的吸收和骨修复。

这项初步研究的目的是研究表面形态,并评估两种脱蛋白牛骨移植材料在大型动物模型的鼻窦移植术后的吸收和骨修复。

使用扫描电子显微镜将新型颗粒状牛骨移植物的表面Moa-Bone与Bio-OssÒ进行比较。然后将六只羊进行双侧上颌窦移植,覆盖BioGideÒ。 4,6和12周后取移植的上颌骨。每个使用树脂嵌入的部分都有一半用于描述愈合。对于另一半,石蜡包埋切片使用抗酒石酸酸性磷酸酶染色破骨细胞活性,runt相关转录因子2免疫组织化学预成骨细胞和成骨细胞和增殖细胞核抗原增殖细胞。

结果:与Bio-OssÒ相比,Moa-BoneÒ更光滑,纤维结构孔更多,球状颗粒更小。 4周后,两种移植物和Moa-BoneÒ颗粒上形成的编织骨也显示出吸收迹象。 12周后,Moa-BoneÒ继续被吸收,而Bio-OssÒ没有;两个移植物都被成熟的片状骨包围。 Moa-BoneÒ与早期Runt相关转录因子2阳性细胞有关。在移植后4周和6周,Moa-BoneÒ而不是Bio-OssÒ与再吸收陷窝内移植物表面的强烈酒石酸耐受性酸性磷酸酶阳性破骨细胞相关。

结论:这两种材料都支持骨愈合和成熟而没有炎症。 Moa-BoneÒ在4周和6周后显示出明显的破骨细胞活性,并且如果需要在该位点完全重建移植物,则表现出移植的积极属性。需要进一步优化Moa-BoneÒ用于颌面部。

原始出处:

M. M. Smith, et al. Attributes of Bio‐OssÒ and Moa‐BoneÒ graft materials in a pilot study using the sheep maxillary sinus model. Journal of Periodontal Research. 2018 February. doi:10.1111/jre.12489

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23:23:17 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301731, encodeId=41cf301e31b7, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Apr 01 10:04:56 CST 2018, time=2018-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=301718, encodeId=f3b0301e18e1, content=希望有机会看到更多类似的经验分享.这样可以让非一线临床工作人员.但又从事该方面工作的人员提供一个直观的解析., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2018-12-22 feather89
  2. 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    2018-04-03 zb1235672

    好知识.值得学习

    0

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    2018-04-02 大爰

    学习了谢谢分享!!

    0

  4. 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  5. 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  6. 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    2018-04-01 orangesking

    .????

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Apr 01 08:42:35 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 明月清辉

    谢谢分享.学习了

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Apr 01 08:42:35 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 虈亣靌

    希望有机会看到更多类似的经验分享.这样可以让非一线临床工作人员.但又从事该方面工作的人员提供一个直观的解析.

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Apr 01 08:42:35 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 龙胆草

    学习谢谢分享

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Apr 01 08:42:35 CST 2018, time=2018-04-01, status=1, ipAttribution=)]
    2018-04-01 sunfeifeiyang

    0