盘点:Lancet杂志7月15日文章一览

2017-07-19 zhangfan MedSci原创

Lancet杂志7月15日文章一览


【1】建立初级医疗保障制度评估方法


基本医疗保障制度对于保持国民健康、降低医疗花费以及保障健康公平发挥着重要的作用,基本医疗保障是一个国家经济以及综合实力的体现。一个完善的基本医疗保障制度十分重要,其特征为以人为中心,全年龄和人生阶段,整合并协调健康发展,预防为主,急慢性疾病治疗和护理、提供公平准入和安全优质护理等。

Christopher Murray等研究人员对1990-2015年间全球195个国家地区的可避免死亡率进行研究以考察其基本医疗保障体系覆盖以及保障情况并建立了医疗保险指数(HAQ)以评价地区之间医保体系随时间的变化。

HAQ指数显示1990-2015年间,全球的医疗保障体系取得了显著进步,通过强化基础医疗建设,提高疫苗接种率和孕产安全护理以可降低婴儿和产妇死亡率,基础医疗体系的建立大大降低了不发达地区人口死亡率。研究发现,韩国,土耳其,秘鲁,中国和马尔代夫是全球医疗保障体系进步最快的5个国家。

【2】氯胺酮不能预防术后谵妄


术后谵妄是一种认知和注意力失调急性事件,其误诊率高,对医护人员、病人以及家属均造成极大的困扰。术后谵妄与术后并发症以及不良预后甚至死亡相关。 Michael Avidan 等研究人员考察了麻醉以及致幻药物--氯胺酮用于预防术后谵妄的效果,但结果令人失望,氯胺酮不能减少术后谵妄的发病率。

【3】Th17抑制剂用于银屑病的治疗


近30年来银屑病发病机制研究取得重大进展,其中之一就是确证了辅助性T细胞17(Th17)在银屑病炎症中的关键作用。Th17淋巴细胞主要通过释放其效应细胞因子白细胞介素17而致病。目前正处于临床研究阶段的Th17抑制剂包括Secukinumab 和 Ixekizumab, 二者均已获准用于中重度银屑病的治疗。

【4】肺动脉栓塞诊断方法研究进展


1964年Sasahara等描述了选择性肺动脉造影在肺栓塞诊断中的应用前景。25年后,肺栓塞诊断的前瞻性研究将使用非侵入性肺通气显像纳入急性肺栓塞的诊断标准。近年来随着CT肺动脉造影的普及,目前肺动脉栓塞的诊断技术不断完善,CT肺动脉造影(CTPA)现已成为肺栓塞诊断的金标准。

【5】急性风湿热以及风湿性心脏病


急性风湿热以及其主要后遗症风湿性心脏病患者的预后较差。急性风湿热是由化脓性链球菌感染引起的咽炎自身免疫反应,其表现为发热、关节炎、心脏瓣膜病、舞蹈病以及皮肤症状。急性风湿热反复发作引起的慢性瓣膜损伤称为风湿性心脏病,是急性风湿热的发病率和死亡率的主要原因。

【6】卒中后的强化言语和语言治疗


Caterina Breitenstein等报道称3周的强化言语和语言治疗可显著提高70岁以及70岁以下慢性脑卒中后失语患者的言语交际能力。研究主要终点通过阿姆斯特丹奈梅亨日常语言测试评估(ANELT),治疗后患者ANELT分数较基线提高2.61分(SD 4.94)。

【7】焦虑症治疗新方法受到质疑


目前心理动力学疗法(PDT)以及认知行为疗法(CBT)是焦虑症临床研究的热点。但近期Craske等研究人员通过荟萃分析发现,超过80%的焦虑症认知行为治疗临床研究使用了候补对照组,导致临床对照性较弱,仅17%的临床研究质量较高,因此研究人员认为认知行为疗法治疗焦虑症仅可能有效。心理疗法用于焦虑症的效果需要进一步的大规模临床验证。

【8】流脑B疫苗可预防淋病


近日WHO公布了最新的淋球菌抗菌素耐药性(AMR)数据,2009-14年间,97%的国家发现耐药淋球菌菌株,其中66%的菌株超级耐药菌。近日研究人员发现一种新的淋病控制途径--14000名接种过流脑B疫苗的新西兰成人新发淋病感染率下降了31%,但必需强调的是安全的性行为是降低淋病传播的最有效途径。

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    2018-03-14 howi
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    2017-07-21 松鼠上树

    学习了。谢谢分享

    0

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    2017-07-19 184****9840

    学习了谢谢分享

    0

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    2017-07-19 大旺旺

    学习了啊

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    2017-07-19 131****1460

    学习了受益匪浅。

    0

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