开滦研究:收缩压变异增加肾脏损伤风险

2017-07-17 佚名 中国循环杂志

开滦总医院吴寿岭、施继红等进行的一项研究显示,短时收缩压变异或会对老年人群肾脏造成损害。研究显示,长时收缩压变异与肾小球滤过率(eGFR)、尿微量白蛋白(ALBU)均无线性线性相关,而24小时收缩压变异指标、日间收缩压变异指标均与eGFR成负相关

开滦总医院吴寿岭、施继红等进行的一项研究显示,短时收缩压变异或会对老年人群肾脏造成损害。

研究显示,长时收缩压变异与肾小球滤过率(eGFR)、尿微量白蛋白(ALBU)均无线性线性相关,而24小时收缩压变异指标、日间收缩压变异指标均与eGFR成负相关。

研究者解释说,短时血压变异主要反映血流动力学、动脉弹性性能和体液的改变,较高的血压变异更能增加血管内皮振荡剪切应力,可促进早期动脉粥样硬化。

在本研究中,更高的短时收缩压变异与蛋白尿和 eGFR 有关联。这可能提示高的短时收缩压变异可能是诱发肾脏损害的初始因素。

该研究纳入开滦研究队列中符合试验标准的2464位≥ 60 岁的受试者,均接受24 小时动态血压监测等检查。

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