J Ethnopharmacol:基于草药提取物的抗微生物肥皂可有效且安全的治疗体癣

2022-05-19 sunshine MedSci原创

Curcuma longa L., Azadirachta indica A Juss. Cassia tora L.在乌纳尼医学中被用于治疗各种皮肤疾病。

Curcuma longa L., Azadirachta indica A Juss. Cassia tora L.在乌纳尼医学中被用于治疗各种皮肤疾病。研究已证实其具有抗微生物、抗细菌、抗真菌、抗病毒、抗氧化、伤口愈合、抗炎症和免疫调节的活性。近日,发表于J Ethnopharmacol的一项单盲随机安慰剂对照试验中研究人员研发了基于此提取物的抗微生物肥皂,并评估其在治疗体癣方面的临床疗效。

抗微生物肥皂由Curcuma longa L.、Azadirachta indica A Juss.和Cassia tora L.的水醇提取物制备而成。纳入30名年龄在18至60岁之间的男女患者,随机分配接受抗微生物香皂或安慰剂香皂,为期4周。每周评估主观参数,包括红斑、瘙痒和脱屑,客观参数包括皮损照片、总症状评分(TSS)和KOH涂片,均在基线和试验结束时评估。

结果显示,试验组的主观参数得到了明显的改善。试验组分别有70%、80%和25%的患者完全缓解了红斑、鳞屑和脱屑,而对照组没有患者得到完全缓解。试验组的平均TSS从8.65 ± 0.6708降至3.05 ± 1.35,P < 0.001。试验组中80%的患者的KOH涂片呈阴性,而对照组中只有20%呈阴性。

综上所述,该研究结果表明,通过修改成方便的剂型,可以更好地利用乌纳尼药物。抗微生物肥皂的配方是通过添加最少的添加剂来达到治疗效果,具有成本低、效益高和副作用小的优点。该研究结果表明,此抗微生物肥皂在管理体癣方面是有效的。此外,还需要对大样本量进行进一步研究,以对进一步明确这些观察结果。

原始出处:

Tabassiya Kowser R, et al., Efficacy of herbal anti-microbial soap in Tinea corporis: A randomized controlled study. J Ethnopharmacol. 2022 Apr 6;287:114934. doi: 10.1016/j.jep.2021.114934.

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    2022-09-03 jj000001
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    2022-09-25 feather88
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    2023-04-13 zll0637
  8. [GetPortalCommentsPageByObjectIdResponse(id=1787794, encodeId=70ec1e8779430, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sat Sep 03 00:36:18 CST 2022, time=2022-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825391, encodeId=cd4a182539123, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Sep 06 05:36:18 CST 2022, time=2022-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811224, encodeId=a7f01811224a1, content=<a href='/topic/show?id=a3a98e2185e' target=_blank style='color:#2F92EE;'>#草药提取物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87218, encryptionId=a3a98e2185e, topicName=草药提取物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b1f500, createdName=zengjiayao, createdTime=Mon Jan 02 21:36:18 CST 2023, time=2023-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1704601, encodeId=07d01e04601f1, content=<a href='/topic/show?id=02c42663077' target=_blank style='color:#2F92EE;'>#体癣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26630, encryptionId=02c42663077, topicName=体癣)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091230776803, createdName=feather88, createdTime=Sun Sep 25 20:36:18 CST 2022, time=2022-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1908704, encodeId=77d51908e04e1, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Sat May 28 15:36:18 CST 2022, time=2022-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788473, encodeId=eb201e8847314, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Wed Jan 11 16:36:18 CST 2023, time=2023-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754699, encodeId=69af1e54699e3, content=<a href='/topic/show?id=b5338e217cd' target=_blank style='color:#2F92EE;'>#草药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87217, encryptionId=b5338e217cd, topicName=草药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff5b36776883, createdName=zll0637, createdTime=Thu Apr 13 04:36:18 CST 2023, time=2023-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1996475, encodeId=07cb19964e5a3, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Tue Feb 07 21:36:18 CST 2023, time=2023-02-07, status=1, ipAttribution=)]
    2023-02-07 yb6560

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