长假聚会放开吃?要注意高尿酸血症

2018-02-18 北京大学第一医院肾脏内科主任医师  周福德   中华检验医学网

我国约有高尿酸血症患者1.2亿,约占总人口的10%。这可能与饮食结构不合理有密切关系。

高尿酸血症的患病率有明显增多趋势。20世纪80年代初期,我国男性高尿酸血症的患病率为1.4%,女性为1.3%。近年来,我国男性高尿酸血症的患病率为8.2%—19.8%,女性为5.1%—7.6%。据估计,目前我国约有高尿酸血症患者1.2亿,约占总人口的10%。这可能与饮食结构不合理有密切关系。

高尿酸血症是指血尿酸偏高。高尿酸血症不等同于痛风,在血尿酸过高者中,约有10%会得痛风。痛风是指尿酸盐结晶在身体器官沉积的病理状态,可表现为反复发作的关节炎、肾结石和慢性肾脏病。

尿酸是人体嘌呤代谢的产物。人体嘌呤来源有两种,自身合成的嘌呤以及摄入嘌呤饮食,后者约占体内总尿酸量的20%。在正常情况下,体内尿酸30%从肠道和胆道排泄,70%经肾脏排泄。肾脏是尿酸排泄的重要器官。人体每天尿酸的产生和排泄保持平衡状态,维持血尿酸于正常水平。当尿酸生成过多或排泄减少时,可以发生高尿酸血症。

那么,哪些因素容易诱发高尿酸血症呢?

一是进食肉类、海鲜、动物内脏、浓肉汤及坚果类食物,饮用啤酒、白酒,或者进行剧烈体育锻炼,均可引起高尿酸血症。

二是长时间服用利尿药、小剂量阿司匹林、复方降压片等药物,可造成肾脏排泄尿酸减少,导致高尿酸血症。

三是高血压糖尿病、肥胖、高脂血症以及慢性肾脏病患者,也容易出现高尿酸血症。

高尿酸血症与肾脏病互为因果

一方面,肾脏排泄尿酸减少可以导致高尿酸血症,此种原因是高尿酸血症的最常见病因,约占90%。

另一方面,尿酸盐结晶在肾脏沉积,可以形成肾结石和慢性肾脏病,出现腰痛、血尿、蛋白尿、高血压和肾功能异常等。有高尿酸血症的慢性肾脏病患者,肾功能恶化速度更快。研究显示,血尿酸每升高1毫克/分升,肾脏病风险增加71%,肾功能恶化风险增加14%。因此,合理治疗高尿酸血症,有利于保护肾脏。

高尿酸血症患者应采取以下治疗方式:

(1)低嘌呤饮食。严格控制肉类、海鲜和动物内脏的摄入,减少菜花、菠菜、蘑菇、四季豆、豌豆和黄豆等食物摄入。

(2)多饮水,少饮酒。每日饮水量保证在1500毫升以上,禁啤酒和白酒,可适量饮红酒。

(3)坚持运动,控制体重。每日中等强度运动30分钟以上,肥胖者应减体重。

(4)碱化尿液。对于痛风、合并心血管病或心血管病危险因素的高尿血酸症者,需要在医生指导下服用别嘌呤醇、苯溴马隆等降尿酸药物。

痛风治疗常见的误区:

(1)血尿酸降至正常水平(低于420微摩尔/升)即可。其实,这并未达到治疗的要求,并不能很好地预防痛风的发作。

(2)过分强调低嘌呤饮食的作用,认为只要严格控制饮食就可以达到治疗效果。其实,由于外源性嘌呤仅占体内总嘌呤的20%,因此,低嘌呤饮食的疗效有限,单纯依靠饮食控制不能起到很好效果。

(3)仅进行短期的治疗就停止了。其实,痛风是慢性病,需要长期治疗。

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    2018-02-20 1209e435m98(暂无昵称)

    学习了.谢谢分享

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    2018-02-20 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-02-19 jyzxjiangqin

    高尿酸血症的治疗.

    0

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    2018-02-18 沙漠浪人

    尿酸生成过多或排泄减少时.可以发生高尿酸血症.

    0

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    2018-02-18 飛歌

    学习了很有用

    0

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    2018-02-18 惠映实验室

    学习.谢谢分享.

    0