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Gastroenterology：抗生素可抑制大鼠肠粘膜肥大细胞激活和减少脂质吸收

2016-07-31 MedSci MedSci原创

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肠道微生物群可影响肠道通透性和粘膜肥大细胞(MMCs)的反应。MMCs激活与膳食中脂质吸收相关。我们探究了是否肠道微生物群促进了大鼠脂质诱导的MMCs激活，以及抗生素是怎样影响这个过程的。 给予成年雄性Sprague-Dawley大鼠链霉素和青霉素4天 (n=6-8)，以减少肠道定植菌群的丰富度，或普通饮用水(对照组，n=6-8)。然后行淋巴漏手术，经过一夜的恢复后，给予十二指肠脂质乳剂。收

肠道微生物群可影响肠道通透性和粘膜肥大细胞(MMCs)的反应。MMCs激活与膳食中脂质吸收相关。我们探究了是否肠道微生物群促进了大鼠脂质诱导的MMCs激活，以及抗生素是怎样影响这个过程的。

给予成年雄性Sprague-Dawley大鼠链霉素和青霉素4天 (n=6-8)，以减少肠道定植菌群的丰富度，或普通饮用水(对照组，n=6-8)。然后行淋巴漏手术，经过一夜的恢复后，给予十二指肠脂质乳剂。收集肠内组织，淋巴液，评估MMCs活化，肠道通透性和脂肪转运参数。

结果：与对照组相比，给予抗生素的大鼠肠道淋巴粘膜肥大细胞蛋白酶II(MMCs产生)水平减少，二胺氧化酶(肠上皮细胞产生)活性下降(P<.05)。试验组大鼠肠道对脂质的渗透性下降 (P<.01)。出乎意料的是，抗生素同时减少了三酰甘油和磷脂(P < . 01)的转运，伴随粘膜载脂蛋白B、AI和A4水平下降(P < . 01)。两组间肠蠕动和胰脂肪酶活性无差异。这些效应在给予抗生素急性剂量和抗生素停药4周后消失。

结论：肠道微生物可激活MMCs，从而影响大鼠的脂质吸收，进而影响脂质引起的肠道脂肪通透性变化。我们发现肠道微生物促进了脂质的吸收，可能是由于肠道产生的载脂蛋白和乳糜微粒导致。

原始出处：

Sato H1, Zhang LS2, Martinez K3, Chang EB3, et al,Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.Gastroenterology. 2016 Jul 16. pii: S0016-5085(16)34786-2.


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    2016-09-22 ms24272190615788285182

    #AST#

    0

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    2016-11-02 许安

    #GAS#

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    2017-02-02 guoyibin

    #粘膜#

    0

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2017-02-10 jktdtl

    #Gastroenterol#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1710893, encodeId=dcdc1e1089303, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Sep 22 01:45:00 CST 2016, time=2016-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071649, encodeId=26d120e16490b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Nov 02 10:45:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690955, encodeId=5d9c169095554, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Thu Feb 02 23:45:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134913, encodeId=dd9713491308, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 09:17:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063984, encodeId=578c2063984e2, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Feb 10 21:45:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504233, encodeId=86121504233b5, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Aug 02 09:45:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569173, encodeId=e8ff15691e323, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Tue Aug 02 09:45:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95339, encodeId=028595339bc, content=学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 31 20:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-08-02 chaojitidian

    #Gastroenterology#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1710893, encodeId=dcdc1e1089303, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Sep 22 01:45:00 CST 2016, time=2016-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071649, encodeId=26d120e16490b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Nov 02 10:45:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690955, encodeId=5d9c169095554, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Thu Feb 02 23:45:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134913, encodeId=dd9713491308, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 09:17:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063984, encodeId=578c2063984e2, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Feb 10 21:45:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504233, encodeId=86121504233b5, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Aug 02 09:45:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569173, encodeId=e8ff15691e323, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Tue Aug 02 09:45:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95339, encodeId=028595339bc, content=学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 31 20:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-08-02 gds2014

    #肥大细胞#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1710893, encodeId=dcdc1e1089303, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Sep 22 01:45:00 CST 2016, time=2016-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071649, encodeId=26d120e16490b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Nov 02 10:45:00 CST 2016, time=2016-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690955, encodeId=5d9c169095554, content=<a href='/topic/show?id=7adce62603e' target=_blank style='color:#2F92EE;'>#粘膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76260, encryptionId=7adce62603e, topicName=粘膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=090129165428, createdName=guoyibin, createdTime=Thu Feb 02 23:45:00 CST 2017, time=2017-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134913, encodeId=dd9713491308, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 09:17:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063984, encodeId=578c2063984e2, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Feb 10 21:45:00 CST 2017, time=2017-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504233, encodeId=86121504233b5, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Aug 02 09:45:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569173, encodeId=e8ff15691e323, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Tue Aug 02 09:45:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=95339, encodeId=028595339bc, content=学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 31 20:20:00 CST 2016, time=2016-07-31, status=1, ipAttribution=)]
    2016-07-31 1dd8c52fm63(暂无匿称)

    学习学习！

    0