J Transl Med:血小板,性别和急性脑梗塞

2015-08-18 phylis 译 MedSci原创

目的:血小板在脑梗塞的发病机制中可能有着重要的意义。性别不同,血小板数量也不同。我们当前的工作是想确定卒中的男性和女性中,血小板活性是否不同。病人和方法:招募了73名患有急性缺血性脑梗塞的病人,其中女性病人32,男性病人42。包括各种卒中类型。应用电子计数血小板数量。应用流式细胞仪分析刺激后血小板表面粘附的纤维蛋白原以表示血小板的活性。应用ADP(1.7μmol/L)和一种凝血酶受体激动剂TRAP

目的:血小板在脑梗塞的发病机制中可能有着重要的意义。性别不同,血小板数量也不同。我们当前的工作是想确定卒中的男性和女性中,血小板活性是否不同。

病人和方法:招募了73名患有急性缺血性脑梗塞的病人,其中女性病人32,男性病人42。包括各种卒中类型。应用电子计数血小板数量。应用流式细胞仪分析刺激后血小板表面粘附的纤维蛋白原以表示血小板的活性。应用ADP(1.7μmol/L)和一种凝血酶受体激动剂TRAP-6 (57 μmol/L)作为血小板激动剂。

结果:女性卒中患者血小板计数较高,但是血小板的活性较低。应用ADP和TRAP-6激动剂,p值分别为(p = 0.038) 和(p = 0.016)。

结论:当前的研究显示女性急性脑梗塞患者血小板活性较低。也就是说,性别影响血小板。我们的研究表明,根据性别不同,可以对卒中患者进行个体化应用血小板抑制剂治疗,这对于不同卒中患者的个体化治疗有益。

原文出处:

Järemo P, Eriksson-Franzen M, Milovanovic M.Platelets, gender and acute cerebral infarction.J Transl Med. 2015 Aug 16;13(1):267.


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    2016-01-20 bsmagic9140
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    2015-08-20 karmond
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    2015-08-18 pine007

    好文

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