JAMA:USPSTF不推荐≥60岁无心血管病老人使用阿司匹林!

2022-05-01 JAMA JAMA

新建议更新了2016年工作组关于使用阿司匹林预防心血管病和直肠癌的建议。

近年来关于阿司匹林在动脉粥样硬化性心血管疾病(ASCVD)一级预防中的作用一直争议不断。

近日,美国预防服务特别工作组(USPSTF)就此发布新声明:不推荐≥60岁老年人使用阿司匹林进行心血管疾病一级预防。

美国预防服务特别工作组评估了阿司匹林一级预防的净获益,认为:

(1)40~59岁、10年心血管疾病风险≥10%的成年人服用阿司匹林用于心血管疾病事件的一级预防具有较小的净获益。

(2)≥60岁的成年人使用阿司匹林作为心血管事件的一级预防并没有净获益,出血的风险大于心血管病的益处。

因此,新声明建议,在40~59岁、10年心血管疾病风险≥10%的成年人使用低剂量(81 mg)阿司匹林作为心血管疾病的一级预防应个体化,不推荐≥60岁的成年人使用低剂量阿司匹林作为心血管疾病的一级预防。

另外,根据24项对主要心血管疾病预防人群证据的最新分析、14项以及妇女健康研究(WHS)的长期随访数据,工作组认为,使用低剂量阿司匹林降低结直肠癌发病率或死亡率的证据不足。

新建议更新了2016年工作组关于使用阿司匹林预防心血管病和直肠癌的建议。

自2016年工作组关于使用阿司匹林预防心血管病和直肠癌的建议发布之后,2018年公布了三项关于阿司匹林一级预防的大型安慰剂对照随机临床试验——ARRIVE研究、ASPREE研究和ASCEND研究,这三项试验足以质疑阿司匹林一级预防的净获益。因此,工作组更新了推荐。

来源

US Preventive Services Task Force. Aspirin Use to Prevent Cardiovascular Disease: US Preventive Services Task Force Recommendation Statement. JAMA. 2022, 327(16): 1577-1584.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1644943, encodeId=d3d11644943e8, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Thu Nov 17 15:30:04 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218800, encodeId=9f1f1218800f6, content=很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a455449587, createdName=无糖去冰, createdTime=Wed May 11 17:55:16 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537041, encodeId=6fa5153e041a8, content=<a href='/topic/show?id=7b6e18196cf' target=_blank style='color:#2F92EE;'>#USPSTF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18196, encryptionId=7b6e18196cf, topicName=USPSTF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue May 03 05:30:04 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243484, encodeId=f951124348438, content=JAMA上文章都是顶级的,谢谢梅斯及时上新, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Sun May 01 17:30:04 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1644943, encodeId=d3d11644943e8, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Thu Nov 17 15:30:04 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218800, encodeId=9f1f1218800f6, content=很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a455449587, createdName=无糖去冰, createdTime=Wed May 11 17:55:16 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537041, encodeId=6fa5153e041a8, content=<a href='/topic/show?id=7b6e18196cf' target=_blank style='color:#2F92EE;'>#USPSTF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18196, encryptionId=7b6e18196cf, topicName=USPSTF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue May 03 05:30:04 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243484, encodeId=f951124348438, content=JAMA上文章都是顶级的,谢谢梅斯及时上新, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Sun May 01 17:30:04 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2022-05-11 无糖去冰

    很实用

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1644943, encodeId=d3d11644943e8, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Thu Nov 17 15:30:04 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218800, encodeId=9f1f1218800f6, content=很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a455449587, createdName=无糖去冰, createdTime=Wed May 11 17:55:16 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537041, encodeId=6fa5153e041a8, content=<a href='/topic/show?id=7b6e18196cf' target=_blank style='color:#2F92EE;'>#USPSTF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18196, encryptionId=7b6e18196cf, topicName=USPSTF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue May 03 05:30:04 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243484, encodeId=f951124348438, content=JAMA上文章都是顶级的,谢谢梅斯及时上新, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Sun May 01 17:30:04 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2022-05-03 heli0118
  4. [GetPortalCommentsPageByObjectIdResponse(id=1644943, encodeId=d3d11644943e8, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Thu Nov 17 15:30:04 CST 2022, time=2022-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218800, encodeId=9f1f1218800f6, content=很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a455449587, createdName=无糖去冰, createdTime=Wed May 11 17:55:16 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537041, encodeId=6fa5153e041a8, content=<a href='/topic/show?id=7b6e18196cf' target=_blank style='color:#2F92EE;'>#USPSTF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18196, encryptionId=7b6e18196cf, topicName=USPSTF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue May 03 05:30:04 CST 2022, time=2022-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243484, encodeId=f951124348438, content=JAMA上文章都是顶级的,谢谢梅斯及时上新, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=肿瘤克星, createdTime=Sun May 01 17:30:04 CST 2022, time=2022-05-01, status=1, ipAttribution=)]
    2022-05-01 肿瘤克星

    JAMA上文章都是顶级的,谢谢梅斯及时上新

    0

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