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Clin J Am Soc Nephrol：分析极低出生体重儿的尿液标志物或可预测急性肾损伤

2016-08-17 Seven L 译 MedSci原创

尿液标志物肾损伤极低出生体重儿
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根据最近的一项前瞻性队列研究，出生后第一个四天的尿生物标志物与出生后第一周急性肾损伤有关。来自伯明翰阿拉巴马大学的David J. Askenazi博士为了探究早产儿尿液肾脏损害，以及尿液肾脏损害能否改善肾损害的检测，他和同事们对2012年2月至2013年6月入住阿拉巴马大学伯明翰分校新生儿ICU的113名极低出生体重儿（体重≤1200克或孕周<31周）进行了研究，评估了14种尿液标志物和A

根据最近的一项前瞻性队列研究，出生后第一个四天的尿生物标志物与出生后第一周急性肾损伤有关。

来自伯明翰阿拉巴马大学的David J. Askenazi博士为了探究早产儿尿液肾脏损害，以及尿液肾脏损害能否改善肾损害的检测，他和同事们对2012年2月至2013年6月入住阿拉巴马大学伯明翰分校新生儿ICU的113名极低出生体重儿（体重≤1200克或孕周<31周）进行了研究，评估了14种尿液标志物和AKI之间的联系。

研究人员测量了出生后1、2、3和4天的血清肌酐（Scr），结合临床测量SCr识别AKI。当SCr≥0.3 mg/dL或从先前低值增加幅度≥50%时定义为AKI。他们收集了前四天的尿液（平均尿液样本量，3；范围，1–4）。研究者计算了最高尿液生物标志物浓度和12种尿液标志物的的生物标志物/肌酐水平，并且计算了最低标志物浓度和2种标志物的标志物/肌酐水平。接着研究者使用这些值比较AKI和非AKI患儿。

113名婴儿中有28名在出生的头两个星期发生了AKI。与非AKI患儿相比，AKI患儿以下值有更高的最大水平：尿胱抑素C（高2倍）、中性粒细胞明胶酶蛋白（高1.8倍）、骨桥蛋白（高1.7倍）、丛生蛋白（高1.7倍）和α-谷胱甘肽S-转移酶（高3.7倍）；以下值有更低的最低水平：上皮生长因子（低1.4倍）和尿调节素（低1.6倍）。

结果表明，极低出生体重儿可以根据出生后四天内的尿生物标志物，预测出生后第一周内发生AKI风险；不过未来还需要更多的研究验证他们之间的关系。

原始出处：

Urine biomarkers in postnatal infants associated with acute kidney injury.Healio.August 17, 2016

Askenazi DJ, et al. Acute Kidney Injury Urine Biomarkers in Very Low-Birth-Weight Infants.Clin J Am Soc Nephrol. 2016;doi 10.2215/CJN.13381215.

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    2016-09-30 hukaixun

    #标志物#

    0

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    2016-09-07 ylzr123

    赞一个！深入学习，探究。

    0

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    2016-09-06 李东泽

    很好，不错，以后会多学习

    0

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    2016-08-24 忠诚向上

    好好学习一下

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1840909, encodeId=13351840909bb, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Sep 30 13:17:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113311, encodeId=d8a211331109, content=赞一个！深入学习，探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 07 17:35:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112574, encodeId=ed721125e414, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 20:52:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102792, encodeId=f028102e92c0, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 24 07:28:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101526, encodeId=5de2101526a8, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLMzGpMQ8w4I7FpiblCXNcmI6O7TDINutbaicEUpoYFR1rWqn3kTbulfMhT0iaPFurLz2ddEcWe3BiciaQ/0, createdBy=5f6e1724878, createdName=136****0753赵, createdTime=Sat Aug 20 15:23:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397049, encodeId=032e139e049a0, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440728, encodeId=0ca01440e28df, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449315, encodeId=829d144931500, content=<a href='/topic/show?id=b3e24e442bc' target=_blank style='color:#2F92EE;'>#尿液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47442, encryptionId=b3e24e442bc, topicName=尿液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66095470791, createdName=zhaohui6733, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571470, encodeId=c75415e147001, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=)]
    2016-08-20 136****0753赵

    值得学习

    0

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    2016-08-19 ms3046638856685384

    #损伤#

    0

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    2016-08-19 ms9608593228839890

    #出生体重#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1840909, encodeId=13351840909bb, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Sep 30 13:17:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113311, encodeId=d8a211331109, content=赞一个！深入学习，探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 07 17:35:00 CST 2016, time=2016-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=112574, encodeId=ed721125e414, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Sep 06 20:52:00 CST 2016, time=2016-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=102792, encodeId=f028102e92c0, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 24 07:28:00 CST 2016, time=2016-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101526, encodeId=5de2101526a8, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLMzGpMQ8w4I7FpiblCXNcmI6O7TDINutbaicEUpoYFR1rWqn3kTbulfMhT0iaPFurLz2ddEcWe3BiciaQ/0, createdBy=5f6e1724878, createdName=136****0753赵, createdTime=Sat Aug 20 15:23:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397049, encodeId=032e139e049a0, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1440728, encodeId=0ca01440e28df, content=<a href='/topic/show?id=f99e3142e4d' target=_blank style='color:#2F92EE;'>#出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31427, encryptionId=f99e3142e4d, topicName=出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5ffd4758992, createdName=ms9608593228839890, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1449315, encodeId=829d144931500, content=<a href='/topic/show?id=b3e24e442bc' target=_blank style='color:#2F92EE;'>#尿液#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47442, encryptionId=b3e24e442bc, topicName=尿液)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66095470791, createdName=zhaohui6733, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571470, encodeId=c75415e147001, content=<a href='/topic/show?id=d13c26153fd' target=_blank style='color:#2F92EE;'>#低出生体重#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26153, encryptionId=d13c26153fd, topicName=低出生体重)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5e7915741670, createdName=linne325, createdTime=Fri Aug 19 14:17:00 CST 2016, time=2016-08-19, status=1, ipAttribution=)]
    2016-08-19 zhaohui6733

    #尿液#

    0

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    2016-08-19 linne325

    #低出生体重#

    0