PLoS Med:低出生体重与18岁前死亡率相关

2016-05-31 Mechront 译 MedSci原创

近期发表在PLoS Medicine的研究表明,英格兰和威尔士极低出生体重的青少年其死亡原因往往是中枢神经系统和呼吸系统的毛病。此外,研究人员还发现,癌症(20%)和意外事故(20%)是低出生体重的青少年的死亡原因。“研究表明,极低出生体重和低出生体重与儿童/青少年死亡率相关,”卡蒂夫大学医学院的Sailesh Kotecha博士写到,“许多18岁以下的死因主要原因包括围产期和婴儿期先天畸形。”研

近期发表在PLoS Medicine的研究表明,英格兰和威尔士极低出生体重的青少年其死亡原因往往是中枢神经系统和呼吸系统的毛病。此外,研究人员还发现,癌症(20%)和意外事故(20%)是低出生体重的青少年的死亡原因。

“研究表明,极低出生体重和低出生体重与儿童/青少年死亡率相关,”卡蒂夫大学医学院的Sailesh Kotecha博士写到,“许多18岁以下的死因主要原因包括围产期和婴儿期先天畸形。”

研究人员写道,虽然低出生体重新生儿在围产期和婴儿期死亡率较高,但仍不清楚是否在青春期死亡率会持续增加。因此,研究人员进行了一项研究,探究全因死亡率关联以及不同出生体重组到18岁死亡的主要原因。

研究纳入了英国和威尔士1993-2011年的12,355,251名活产儿,极低出生体重儿(VLBW)为500-1499g,低出生体重(LBW)为1500-2499g。

结果显示,LBW与后来的儿童和青少年死亡率相关。Kotecha还发现,0.61%的参与者死于出生和18岁之间,23%的死亡发生于婴儿后期。在婴儿期,围产期因素,主要是感染和呼吸问题,是VLBW(84%)和低LBW(31%)死亡的主要原因。在此期间,研究人员发现先天畸形位居VLBW(36%)和低LBW(23%)死亡原因第二位。在儿童期和青少年期,神经系统(20%)和呼吸系统(16%)是VLBW死亡主要原因;癌症(20%)和交通事故(20%)是LBW组死亡主要原因。

“临床医生需要了解和改善上游风险,如母亲吸烟,可降低LBW婴儿出生率,进而降低未来死亡率,”研究者写道,“专注于上游风险,防止低出生体重仍然是一个重要的健康目标。”

原始出处:


Watkins WJ, et al. All-Cause Mortality of Low Birthweight Infants in Infancy, Childhood, and Adolescence: Population Study of England and Wales.PLoS Med. 2016;doi:10.1371/journal.pmed.1002018.

Low, very low birth weight linked to mortality during adolescence.
Healio.May 31, 2016

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    2016-06-01 沉心多思

    先天的重要性

    0

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    2016-06-01 1dd8c52fm63(暂无匿称)

    学习一下!

    0

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    2016-06-01 milkshark

    是这样的

    0

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    2016-06-01 milkshark

    先天很重要

    0

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    2016-05-31 明崖

    学习了,算是先天不足

    0

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