Stroke:硝酸甘油对急性脑卒中患者血流动力学的影响

2019-02-17 不详 MedSci原创

众所周知,血压,心率的增加与急性卒中的不良临床结果相关。因此本项研究旨在评估三硝酸甘油酯(GTN)对血液动力学参数的影响。

背景和目的
众所周知,血压,心率的增加与急性卒中的不良临床结果相关。因此本项研究旨在评估三硝酸甘油酯(GTN)对血液动力学参数的影响。

方法
研究人员将急性卒中和血压升高的患者在其发病后48小时内随机分配至GTN治疗组或无GTN 治疗组,总共进行7天试验。对所有参与者评估其在第1天至第7天之间的血压变异性,最后对基线预后变量进行分析。

结果
基线血压,心率和速率-压力积的增加均与第90天的不良功能结果相关。收缩压变异的增加与改良Rankin量表的恶化评分相关,使用GTN后在第1天降低血压和速率压力产物并增加心率,并会减少收缩压的变异性。

结论
本项研究表明血压变异性增加与功能和认知结果评分较差以及急性卒中后90天死亡率增加相关。GTN治疗可以降低访视期间收缩压的变异性。

原始出处:

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    2019-02-17 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0