JCEM:别再熬夜,小心患代谢疾病!

2015-04-06 徐媛媛译 MedSci原创

睡眠类型可以决定个体生理特征偏好和相对于外部的生物节律。然而,很少有人知道睡眠类型和代谢紊乱的关系。 本研究的目的是研究睡眠类型是否与代谢异常、成年人身体成分,睡眠时间和生活方式有关。 收纳了来自韩国基因组和流行病学研究中的1620名47-59岁的参与者,采用早晨型-夜晚型人格量表(morningness-eveningness questionnaire, MEQ)进行评估。所有参与者进行口

睡眠类型可以决定个体生理特征偏好和相对于外部的生物节律。然而,很少有人知道睡眠类型和代谢紊乱的关系。

本研究的目的是研究睡眠类型是否与代谢异常、成年人身体成分,睡眠时间和生活方式有关。

收纳了来自韩国基因组和流行病学研究中的1620名47-59岁的参与者,采用早晨型-夜晚型人格量表(morningness-eveningness questionnaire, MEQ)进行评估。所有参与者进行口服葡萄糖耐量试验和检查身体成分的DEXA检查。内脏肥胖被指定为内脏脂肪面积来衡量腹部断层扫描(> 100平方厘米)。

结果:29.6%的参与者属于早上型,5.9%的参与者属于晚上型,64.5%的参与者同属于这两者。在校正潜在混杂因素后,相比早上型,夜晚型与糖尿病(OR=1.73; 95% CI, 1.01-2.95)、代谢综合征(OR=1.74; 95% CI, 1.05-2.87)和肌肉减少症(OR=3.16; 95% CI, 1.36-7.33)发生风险增加有显著相关性。研究人员还发现这种风险增加有性别差异。与早睡早起者相比,夜猫子发生糖尿病及代谢综合征的风险可分别增加73%和74%,肌肉减少症风险可增加两倍多。对于男性,夜晚型与糖尿病(OR=2.98; 95% CI, 1.39-6.39)和肌肉减少症(OR=3.89; 95% CI, 1.33-11.33)均相关,而女性夜晚型仅与代谢综合征(OR=2.22; 95% CI, 1.11-4.43)相关。

研究表明:即使睡眠总时间一样,习惯熬夜的人群发生糖尿病、代谢综合征和肌肉减少症的风险也高于早睡早起的人群。

原始出处

Yu JH1, Yun CH, Ahn JH, Suh S, Cho HJ, Lee SK, Yoo HJ, Seo JA, Kim SG, Choi KM, Baik SH, Choi DS, Shin C, Kim NH.Evening Chronotype Is Associated With Metabolic Disorders and Body Composition in Middle-Aged Adults.J Clin Endocrinol Metab. 2015 Apr 1

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    2015-09-08 achengzhao
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    2015-10-15 smallant2015
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    2015-06-11 ljjj1053

    好好学习一下

    0

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    2015-04-11 sunqi2001

    什么时候做一个夜班次数和代谢紊乱相关性研究吧

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2062889, encodeId=d66f206288910, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Sep 08 00:56:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777507, encodeId=1b711e77507de, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Oct 15 03:56:00 CST 2015, time=2015-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27088, encodeId=83392e088be, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Thu Jun 11 18:40:00 CST 2015, time=2015-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20432, encodeId=94af2043201, content=什么时候做一个夜班次数和代谢紊乱相关性研究吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bec31378570, createdName=sunqi2001, createdTime=Sat Apr 11 22:57:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401986, encodeId=afa81401986ee, content=<a href='/topic/show?id=193025463d8' target=_blank style='color:#2F92EE;'>#代谢疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25463, encryptionId=193025463d8, topicName=代谢疾病)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/F9591315BE4091482318EFFCD39C9D08/100, createdBy=bf9f2374681, createdName=windight, createdTime=Wed Apr 08 10:56:00 CST 2015, time=2015-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19869, encodeId=234519869b5, content=确实不能再熬夜了, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Tue Apr 07 16:01:00 CST 2015, time=2015-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19751, encodeId=ad6819e5191, content=不敢熬夜了。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Apr 07 09:30:00 CST 2015, time=2015-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19641, encodeId=f91c1964186, content=对预防糖尿病健康教育有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63461620684, createdName=yuena, createdTime=Mon Apr 06 22:04:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19631, encodeId=59cd1963130, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CRAZYDAFF, createdTime=Mon Apr 06 20:40:00 CST 2015, time=2015-04-06, status=1, ipAttribution=)]
    2015-04-07 Johnny1989

    确实不能再熬夜了

    0

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    2015-04-07 MedSci客户端网友

    不敢熬夜了。。。

    0

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    2015-04-06 yuena

    对预防糖尿病健康教育有用

    0

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    2015-04-06 CRAZYDAFF

    有意思

    0

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当生物钟被打乱时,肠道内的TH17细胞会引发疾病。 时差反应、轮班工作,甚至在深夜玩平板电脑或智能手机都可能让你生病。这是因为人体生理反应的节奏跟昼夜交替一致,一旦这个节奏被破坏,人体内的生物钟发生紊乱,人们免疫系统的抗病能力就会降低。根据一项新研究,一个可能的解释是,控制生物钟的基因和某些免疫细胞密切相关。 地球物种在进化的过程中逐渐演化出一套计时系统,也就是所谓生物钟。有了生物钟这种机制,

熬通宵对身体危害有多大?科学家试图获取标志物

在做重要报告之前通宵熬夜的危害有多大?长期每天睡眠不足七小时仅仅是一个困扰,抑或是一个严重的健康风险?如果拥有一个衡量自己需要多长时间睡眠的严格标准,人们就可以采取措施来抵挡倦意。 人人都知道通宵赶报告伤害身体,但是这种伤害到底有多大?科学家正在研究人体内疲倦的生物标记物,比如蛋白质、淀粉,以此来衡量人体的疲倦程度。当然,睡眠研究的这一领域尚处于初级阶段,真正付诸生物学实验可能还要等到数年之后。

Nat Neurosci:美研究发现新型生物钟调节“按钮”

近日,刊登在国际著名杂志Nature Neuroscience上的一篇研究论文中,来自美国范德堡大学的研究人员通过研究发现了调节生物钟的新型“复位按钮”,研究者表示,这种大脑生物钟复位按钮的发现对于后期开发治疗许多疾病的新型疗法提供了新的思路,比如治疗季节性情感障碍等,同时也可以帮助降低通宵熬夜工作带来的健康影响。 研究者Douglas McMahon教授表示