可卡因上瘾与大脑结构异常有关
2011-06-23 MedSci原创 MedSci原创
可卡因上瘾与大脑结构异常有关 英国一项最新研究说,对毒品可卡因上瘾者大脑中某些功能性结构会存在异常,这项研究或许有助于找到戒除毒瘾的方法。 英国剑桥大学研究人员在新一期学术刊物《脑》上报告说,他们利用磁共振成像仪扫描了60名可卡因上瘾者的大脑,然后与另60名普通人的大脑进行对比,结果发现,可卡因上瘾者大脑中的眼窝前额皮质等部位的灰质明显较少。 &nbs
可卡因上瘾与大脑结构异常有关 |
Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence
A growing body of preclinical evidence indicates that addiction to cocaine is associated with neuroadaptive changes in frontostriatal brain systems. Human studies in cocaine-dependent individuals have shown alterations in brain structure, but it is less clear how these changes may be related to the clinical phenotype of cocaine dependence characterized by impulsive behaviours and compulsive drug-taking. Here we compared self-report, behavioural and structural magnetic resonance imaging data on a relatively large sample of cocaine-dependent individuals (n = 60) with data on healthy volunteers (n = 60); and we investigated the relationships between grey matter volume variation, duration of cocaine use, and measures of impulsivity and compulsivity in the cocaine-dependent group. Cocaine dependence was associated with an extensive system of abnormally decreased grey matter volume in orbitofrontal, cingulate, insular, temporoparietal and cerebellar cortex, and with a more localized increase in grey matter volume in the basal ganglia. Greater duration of cocaine dependence was correlated with greater grey matter volume reduction in orbitofrontal, cingulate and insular cortex. Greater impairment of attentional control was associated with reduced volume in insular cortex and increased volume of caudate nucleus. Greater compulsivity of drug use was associated with reduced volume in orbitofrontal cortex. Cocaine-dependent individuals had abnormal structure of corticostriatal systems, and variability in the extent of anatomical changes in orbitofrontal, insular and striatal structures was related to individual differences in duration of dependence, inattention and compulsivity of cocaine consumption.
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在此留言
#上瘾#
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希望楼主多多发一些关于大脑的文献之类!!谢谢
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#大脑结构#
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#可卡因#
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#脑结构#
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