J Hepatology: 健康生活方式可以改善非酒精性脂肪性肝病患者的病情

2018-12-20 MedSci MedSci原创

大约10-20%的非酒精性脂肪性肝病(NAFLD)患者是非肥胖类型的。这些患者体重减轻的好处尚不明确,因此本项研究的目的是研究生活方式干预对NAFLD非肥胖患者的疗效,并确定预测治疗反应的因素。

背景与目的
大约10-20%的非酒精性脂肪性肝病(NAFLD)患者是非肥胖类型的。这些患者体重减轻的好处尚不明确,因此本项研究的目的是研究生活方式干预对NAFLD非肥胖患者的疗效,并确定预测治疗反应的因素。

方法
共有154名NAFLD患者被随机分配到12个月的生活方式干预试验。主要观察结果是在第12个月通过质子 - 磁共振波谱法检测NAFLD缓解的情况。体重指数(BMI)截止值为25kg/m2用于定义非肥胖NAFLD。

结果
干预组和对照组分别有77名患者,(每组39和38组的基线BMI分别<25和≥25kg/m2)。无论基线BMI如何,干预组中的患者均达到主要观察指标,生活方式干预,较低的基线肝内甘油三酯,以及体重和腰围的减少是与非肥胖患者NAFLD缓解相关的独立影响因素。一半的非肥胖患者实现了NAFLD缓解,体重减轻3-5%; 只有体重减轻7-10%的肥胖患者才能达到同样的效果。

结论
生活方式干预可有效治疗非肥胖和肥胖患者的NAFLD。减轻体重可预测非肥胖患者NAFLD的缓解。

原始出处:

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  4. 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    2019-08-01 qjddjq
  5. 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  6. 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  7. 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  8. 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    2018-12-22 gwc384

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