JAHA:使用立体定位放射外科手术进行猪房室结消融:心律失常无导管消融的可行性研究

2017-10-30 xiangting MedSci原创

无导管放射消融—使用基于直线加速器的立体定位放射外科手术在完整的猪模型中是可行的。

可以传导到心律失常病灶基于直线加速器的立体定位放射外科手术是一种有前景的无导管消融模式。研究人员使用立体定位放射外科手术测试了在猪体内进行房室(AV)节消融的可行性。

共研究了 5只大白品种猪(重量40-75kg; 4只为雌性)。每只猪均植入了单室St Jude起搏器。将猪进行全身麻醉后,进行冠脉/心脏计算机断层模拟扫描以定位AV节。锥束CT扫描用于目标定位。立体定位放射外科手术剂量范围为35至40 Gy,通过直线加速器递送至AV节,并对猪每周进行起搏器检查以观察潜在的心电图变化。一旦观察到变化,即将猪进行安乐死,并将各种组织的病理标本,包括AV结和AV节周围的组织用来研究辐射的影响。5只猪都有AV传导障碍,并逐渐转变为完全心脏阻滞。宏观检查显示没有心肌损伤,猪在超声心动图上保留了收缩功能。免疫染色显示AV结的目标区域有纤维化,而非目标区域没有检测到纤维化。

无导管放射消融-使用基于直线加速器的立体定位放射外科手术在完整的猪模型中是可行的。

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    2017-11-01 zhaohui6731
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    2017-11-01 muzishouyi
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    2017-10-30 131****1460

    学习了受益匪浅

    0

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