淋巴结阳性胃癌患者生存率与放疗有关

2012-05-25 魏冬 医学论坛网

     《美国临床肿瘤学杂志》(American Journal of Clinical Oncology)近期发表的一项研究表明,淋巴结阳性胃癌患者生存率与放疗有关,并且这种相关性不受手术切除和淋巴结清扫范围的影响。   该研究分析了监督、流行病学和终末事件(SEER)数据库1990~2003年接受手术切除的非转移性胃癌患者的资料,并进行统计分析。   结果显示,共有11603例患者符合

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  《美国临床肿瘤学杂志》(American Journal of Clinical Oncology)近期发表的一项研究表明,淋巴结阳性胃癌患者生存率与放疗有关,并且这种相关性不受手术切除和淋巴结清扫范围的影响。

  该研究分析了监督、流行病学和终末事件(SEER)数据库1990~2003年接受手术切除的非转移性胃癌患者的资料,并进行统计分析。

  结果显示,共有11603例患者符合研究入组标准。

  放疗与美国癌症联合委员会(AJCC)分期ⅠB~Ⅳ期患者生存率提高有关。

  接受放疗的ⅠB和Ⅱ期患者中位生存期分别为96和37个月,未接受辅助放疗的患者分别为56和23个月(ⅠB期:P=0.0281,Ⅱ期:P<0.0001)。

  接受和未接受辅助放疗的淋巴结阳性患者的5年总生存率分别为30.4% 和21.4%(P<0.0001)。

  在≥15枚淋巴结被切除的N1和N2期患者和≥30枚淋巴结被切除的N3期患者中,放疗仍然有益于患者生存。

  在≥15枚淋巴结被切除的淋巴结阳性患者中,辅助放疗与接受胃部分切除术、全切除术和en bloc联合其他器官切除术的患者生存率提高有关。

  多变量分析显示,放疗与患者生存状况呈独立的强相关性。

  相关链接:Adjuvant Radiation Therapy Increases Overall Survival in Node-Positive Gastric Cancer Patients With Aggressive Surgical Resection and Lymph Node Dissection: A SEER Database Analysis



    

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    2012-05-27 sodoo
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