Int Ophthalmol.:过敏性结膜炎中亚硝酸盐、新蝶呤和的色氨酸降解水平变化!

2017-08-09 cuiguizhong MedSci原创

土耳其埃尔祖鲁姆眼科的Cinici E近日在Int Ophthalmol杂志上发表了一项有趣的工作,标题为"Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis",Th1型免疫反应和一氧化氮代谢可能参与过敏性炎症,因此他们主要研究了在Th1型免疫反应和一氧化氮代谢过程中新蝶呤水平和色氨酸降解的

土耳其埃尔祖鲁姆眼科的Cinici E近日在Int Ophthalmol杂志上发表了一项有趣的工作,标题为"Nitrite, neopterin levels and tryptophan degradation in allergic conjunctivitis",Th1型免疫反应和一氧化氮代谢可能参与过敏性炎症,因此他们主要研究了在Th1型免疫反应和一氧化氮代谢过程中新蝶呤水平和色氨酸降解的变化情况。

他们对36例季节性过敏结膜炎患者和41名健康受试者进行了研究,测量了他们血清中亚硝酸、犬尿氨酸、色氨酸和新蝶呤水平,并将这些所有的测量参数与症状比较,进行打分。

结果他们发现,与健康受试者相比,季节性过敏结膜炎患者血清中色氨酸和犬尿氨酸浓度没有显着差别,而亚硝酸盐浓度显着降低,新蝶呤水平显着升高(p <0.05)。同时,他们发现,患者症状评分与血清中亚硝酸盐水平之间存在显着的相关性。

因此,他们认为,在过敏性结膜炎中,血清中一氧化氮代谢过程可能起重要的作用。同时,他们发现,相对血清中色氨酸代谢来说,血清中新蝶呤水平可以作为季节性过敏结膜炎患者的生物标志物。这项工作为治疗季节性过敏结膜炎提供了有力的临床证据。

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topicList=[TopicDto(id=94050, encryptionId=f09c9405003, topicName=过敏性结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bee23217751, createdName=mhzhuang@stu.e, createdTime=Wed Oct 11 14:56:00 CST 2017, time=2017-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677488, encodeId=5aff16e74884e, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Thu May 17 13:56:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027169, encodeId=07f9202e169a7, content=<a href='/topic/show?id=15e458662c1' target=_blank style='color:#2F92EE;'>#新蝶呤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58662, encryptionId=15e458662c1, topicName=新蝶呤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Jan 18 02:56:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756252, encodeId=b8721e562527d, content=<a href='/topic/show?id=0249e354370' target=_blank style='color:#2F92EE;'>#硝酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73543, encryptionId=0249e354370, topicName=硝酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29e537091297, createdName=paperyu, createdTime=Sun Jan 07 01:56:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), 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createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Aug 12 00:03:01 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541259, encodeId=d207154125960, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Fri Aug 11 14:56:00 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232071, encodeId=598c2320e149, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Aug 10 07:49:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232034, encodeId=37ce2320342f, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Aug 10 06:43:32 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
    2018-01-18 cy0324
  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Aug 10 07:49:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232034, encodeId=37ce2320342f, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Aug 10 06:43:32 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
    2018-01-07 paperyu
  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Aug 10 07:49:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232034, encodeId=37ce2320342f, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Aug 10 06:43:32 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
  7. 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style='color:#2F92EE;'>#新蝶呤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58662, encryptionId=15e458662c1, topicName=新蝶呤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Thu Jan 18 02:56:00 CST 2018, time=2018-01-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1756252, encodeId=b8721e562527d, content=<a href='/topic/show?id=0249e354370' target=_blank style='color:#2F92EE;'>#硝酸盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73543, encryptionId=0249e354370, topicName=硝酸盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29e537091297, createdName=paperyu, createdTime=Sun Jan 07 01:56:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Aug 10 07:49:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232034, encodeId=37ce2320342f, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Aug 10 06:43:32 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
    2017-08-12 1e0ece0dm09(暂无匿称)

    谢谢分享

    0

  8. 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  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Aug 10 07:49:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232034, encodeId=37ce2320342f, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Aug 10 06:43:32 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
    2017-08-10 中医痴

    不错的,学习了,谢谢分享!

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=2046865, encodeId=9e3a2046865b6, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Tue Feb 27 16:56:00 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232634, encodeId=b04323263421, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Sat Aug 12 00:03:01 CST 2017, time=2017-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541259, encodeId=d207154125960, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Fri Aug 11 14:56:00 CST 2017, time=2017-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232071, encodeId=598c2320e149, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Aug 10 07:49:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=232034, encodeId=37ce2320342f, content=学习了,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Aug 10 06:43:32 CST 2017, time=2017-08-10, status=1, ipAttribution=)]
    2017-08-10 惠映实验室

    学习了,谢谢。

    0

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