Diabetes Care:2型糖尿病患者夜间低血糖对睡眠的影响

2015-10-09 徐媛 MedSci原创

本研究目的是探讨夜间低血糖对睡眠的影响。在这个单盲,交叉试验中,研究人员收纳了26名2型糖尿病患者,被收纳的患者被随机分配到两组,一组是夜间血糖正常,另外一组是夜间血糖降低。夜间低血糖症的患者在睡眠第2阶段(N2)时,通过停止葡萄糖注射使患者的血糖降低到2.7-2.8mmol/L并维持15分钟,此后再恢复患者血糖至正常水平,并且在整夜的其他时间段血糖维持在正常水平。在血糖正常夜晚,患者血糖维持在5

本研究目的是探讨夜间低血糖对睡眠的影响。

在这个单盲,交叉试验中,研究人员收纳了26名2型糖尿病患者,被收纳的患者被随机分配到两组,一组是夜间血糖正常,另外一组是夜间血糖降低。夜间低血糖症的患者在睡眠第2阶段(N2)时,通过停止葡萄糖注射使患者的血糖降低到2.7-2.8mmol/L并维持15分钟,此后再恢复患者血糖至正常水平,并且在整夜的其他时间段血糖维持在正常水平。在血糖正常夜晚,患者血糖维持在5.0 - 7.0 mmol/L 。

在前4小时的睡眠(0 - 4 h,在睡眠阶段N2之后)时,夜间低血糖和夜间血糖正常相比,觉醒率并无差异。然而,与夜间血糖正常相比,睡眠4-8个小时,夜间低血糖患者觉醒率下降27%;睡眠0-8小时,觉醒率下降20%(都具有统计学意义)。研究人员还发现夜间低血糖受试者睡眠时间更长(低血糖患者和血糖正常患者平均睡眠时间为366min VS 349min)。

睡眠4-8个小时,夜间低血糖导致2型糖尿病患者觉醒反应事件降低。这些发现强调了低血糖相关风险,因为低血糖潜在影响患者的觉醒能力及对碳水化合物充足摄入的反应能力。

原始出处

Jennum P1, Stender-Petersen K2, Rabøl R2, Jørgensen NR3, Chu PL4, Madsbad S5.The Impact of Nocturnal Hypoglycemia on Sleep in Subjects With Type 2 Diabetes.Diabetes Care. 2015 Sep 25. 

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    2015-10-11 hlycom3356

    感谢作者分享

    0

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