NEJM:可卡因致冠状动脉血管痉挛-案例报道

2016-02-04 chenshuo译 MedSci原创

http://www.nejm.org/doi/full/10.1056/NEJMicm1503339

女性,58岁,因出现间歇性胸部疼痛2天而被送往医院急诊,每次疼痛发作持续时间为15分钟。曾通过舌下含服硝酸甘油、氢可酮和对乙酰氨基酚等药物进行缓解。


据了解,该患者既往有高血压和高血脂症病史,另外还有吸烟和喝酒史。



该患者主诉,在2个月前她也曾发作过类似的症状,当时冠状动脉造影显示冠状动脉解剖生理正常(请点击原始链接观看视频)。会诊医师诊断其患上了心包炎,出院后以秋水仙碱和布洛芬药物对其进行治疗。

心电图检查结果显示其心脏前壁T波倒置(如图A所示),而在这之前她的心电图检查中也曾发现有此现象。

在之前的检查中,她的肌钙蛋白I水平为0.04ng/ml(正常值为0-0.03ng/ml);而这次来院检查的结果上升到5.7ng/ml,并在6小时内达到高峰,随之回落至0.71ng/ml。

经胸作超声心动图检查(请观看视频2)显示心包积液,心室功能正常,未见异常室壁运动。最后,医生诊断其患有心肌炎,并应用糖皮质激素口服进行治疗。

住院期间第三天,该患者发生了心脏骤停。医生当即对其进行心肺复苏,5分钟后该患者循环恢复。当再次心电图检查结果显示外侧壁和下壁导联ST段明显抬高2毫米以及前壁ST段压低1-2毫米(如图B所示)。

急性冠状动脉造影(视频3)显示严重的冠状动脉痉挛,主要累及左主干和左前降支。

在尿检中,发现可卡因试验为阳性。由此可见,该患者在住院期间有使用过可卡因药物,从而导致了冠状动脉痉挛的发作。

不久后,该患者死于心肌梗死并发症。

原始出处:

Nureddin Almaddah, M.D., and Tokunbo O. Ajayi, M.D.Cocaine-Induced Coronary-Artery VasospasmN Engl J Med 2016; 374:e5February 4, 2016DOI: 10.1056/NEJMicm1503339


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    2016-02-05 apoenzyme
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    2016-02-05 winter9345

    受教了

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