Stroke:对于TIA患者,那些扑朔迷离的非典型临床症状!

2017-06-14 shaosai MedSci原创

相对于典型的一过性缺血症状(TS),非典型的短暂性脑缺血症状主要包括部分感觉缺失、构音障碍、眩晕或不稳,少见的皮层性视觉障碍和复视。当这些症状单独发生时,临床医生往往不能将此归类于短暂性脑缺血发作(TIA)的临床症状,同时,该种情况的临床发生率尚不明确。本研究纳入了2003-2008年间短暂性脑缺血发作临床中心收治的典型的TIA患者,并对颅脑、动脉及心脏进行了系统的检查。在排除主要鉴别诊断之后,研

单发的非典型短暂性缺血相对于典型的一过性缺血症状(TS),非典型的短暂性脑缺血症状主要包括部分感觉缺失、构音障碍、眩晕或不稳,少见的皮层性视觉障碍和复视。当这些症状单独发生时,临床医生往往不能将此归类于短暂性脑缺血发作(TIA)的临床症状,同时,该种情况的临床发生率尚不明确。

本研究纳入了2003-2008年间短暂性脑缺血发作临床中心收治的典型的TIA患者,并对颅脑、动脉及心脏进行了系统的检查。在排除主要鉴别诊断之后,研究人员将入组患者分为具有单发典型、非典型短暂性脑缺血症状的患者和复合短暂性脑缺血症状的患者三组,并比较三组患者颅脑新发病灶发生率、主要临床检查结果(症状性颅内或颅外动脉粥样硬化狭窄≥50%、颈动脉夹层和主要心源性栓塞来源)、大血管事件1年发生危险率。

在1850例可能或明确缺血性诊断的患者中,798例(43.1%)表现为单发的TS,其中621例(33.6%)症状典型,另外 177例(9.6%)症状不典型。与复合TS患者相比,单发TS发生颅脑成像急性脑梗死阳性的概率要低,而在典型症状患者与非典型患者之间并无明显差别,分别为15.3%、10.0%、11.5%,差异无统计学意义(P <0.0001)。 主要临床检查指标结果分别为18.1%,26.4%和26.3%(P = 0.06)。大血管事件1年内发生的风险在3组中没有显着差异。

研究表明,当出现单发非典型的TS时,临床医生要将TIA的诊断纳入考虑当中。

原始出处:

Philippa C. Lavallée, Leila Sissani, Julien Labreuche, et al. Clinical Significance of Isolated Atypical Transient Symptoms in a Cohort With Transient Ischemic Attack Stroke. 2017. DOI: 10.1161/STROKEAHA.117.016743

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    2017-08-05 马龙
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    2017-06-30 shaosai

    好好学习,涨知识

    0

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