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Colloids Surf B Biointerfaces：Ag-RGO纳米复合材料具有良好的抗菌及抗癌潜能

2018-03-09 MedSci MedSci原创

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目前，具有明显抗菌活性和低细胞毒性的纳米材料吸引了越来越多研究人员的兴趣。Ag-RGO纳米复合材料通过Ag和氧化石墨烯（GO）的抗菌活性，采用一锅法和简易技术制备，分别使用大肠杆菌和胶质母细胞瘤细胞（U87MG）评估其抗菌活性和细胞毒性。通过微量稀释和菌落计数方法研究抗菌活性以研究细胞活力。使用MTT测定法测定成胶质细胞瘤细胞的活力。结果显示，纳米复合材料的MIC和MBC值分别为20和40μg/

目前，具有明显抗菌活性和低细胞毒性的纳米材料吸引了越来越多研究人员的兴趣。Ag-RGO纳米复合材料通过Ag和氧化石墨烯（GO）的抗菌活性，采用一锅法和简易技术制备，分别使用大肠杆菌和胶质母细胞瘤细胞（U87MG）评估其抗菌活性和细胞毒性。

通过微量稀释和菌落计数方法研究抗菌活性以研究细胞活力。使用MTT测定法测定成胶质细胞瘤细胞的活力。结果显示，纳米复合材料的MIC和MBC值分别为20和40μg/ mL，因此可用作杀菌剂，且其抗菌性能与时间和浓度有关。

此外，研究人员还探究了纳米复合材料抗菌活性的动力学和机理。Ag-RGO纳米复合材料的抗菌活性由捕获-杀灭过程诱导。从结果中，我们得出结论，Ag-RGO纳米复合材料可以同时诱导细胞凋亡。

由此研究结果或可设想将在纳米复合材料中使用银纳米粒子，并在抗菌应用中减少氧化石墨烯的使用量。而且，Ag-RGO纳米复合材料可以以剂量依赖性方式降低U87MG的活力，这可能表现出其抗癌潜力。

原始出处：

Moghayedi M, Goharshadi EK, et al., Kinetics and mechanism of antibacterial activity and cytotoxicity of Ag-RGO nanocomposite. Colloids Surf B Biointerfaces. 2017 Nov 1;159:366-374. doi: 10.1016/j.colsurfb.2017.08.001. Epub 2017 Aug 4.

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    2018-03-31 shanyongle

    #ACE#

    0

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    2018-05-18 夏天与十三菇凉

    #FAC#

    0

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    2018-04-26 cooco

    #纳米复合材料#

    0

  4. 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level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Nov 15 19:21:00 CST 2018, time=2018-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783318, encodeId=42751e83318f8, content=<a href='/topic/show?id=f16a499652' target=_blank style='color:#2F92EE;'>#Coll#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4996, encryptionId=f16a499652, topicName=Coll)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=07f7192, createdName=waiwai3030, createdTime=Sat Oct 13 10:21:00 CST 2018, time=2018-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054511, encodeId=eb70205451115, content=<a href='/topic/show?id=517c42615ef' target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jun 05 03:21:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322199, encodeId=4260322199a6, content=方法发个各行各业天天, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Thu Jun 07 08:33:20 CST 2018, time=2018-06-07, status=1, ipAttribution=), 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createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-11-15 sunylz

    #Bio#

    0

  5. 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target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jun 05 03:21:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322199, encodeId=4260322199a6, content=方法发个各行各业天天, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Thu Jun 07 08:33:20 CST 2018, time=2018-06-07, status=1, ipAttribution=), 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createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-10-13 waiwai3030

    #Coll#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1655840, encodeId=760b16558409e, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Sat Mar 31 21:21:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956677, encodeId=daac19566e7af, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, 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target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jun 05 03:21:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322199, encodeId=4260322199a6, content=方法发个各行各业天天, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Thu Jun 07 08:33:20 CST 2018, time=2018-06-07, status=1, ipAttribution=), 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createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-05 医者仁心

    #复合材料#

    0

  7. 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target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jun 05 03:21:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322199, encodeId=4260322199a6, content=方法发个各行各业天天, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Thu Jun 07 08:33:20 CST 2018, time=2018-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321882, encodeId=311f32188294, content=这睡觉睡觉就是就是, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Wed Jun 06 09:17:08 CST 2018, time=2018-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321656, encodeId=3d7832165684, content=消化消化好多好多话, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-07 陈方郑

    方法发个各行各业天天

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1655840, encodeId=760b16558409e, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Sat Mar 31 21:21:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956677, encodeId=daac19566e7af, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, 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target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jun 05 03:21:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322199, encodeId=4260322199a6, content=方法发个各行各业天天, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Thu Jun 07 08:33:20 CST 2018, time=2018-06-07, status=1, ipAttribution=), 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createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-06 陈方郑

    这睡觉睡觉就是就是

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1655840, encodeId=760b16558409e, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Sat Mar 31 21:21:00 CST 2018, time=2018-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956677, encodeId=daac19566e7af, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, 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createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-05 陈方郑

    消化消化好多好多话

    0

  10. 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target=_blank style='color:#2F92EE;'>#复合材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42615, encryptionId=517c42615ef, topicName=复合材料)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Jun 05 03:21:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322199, encodeId=4260322199a6, content=方法发个各行各业天天, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Thu Jun 07 08:33:20 CST 2018, time=2018-06-07, status=1, ipAttribution=), 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createdName=陈方郑, createdTime=Tue Jun 05 11:45:56 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321373, encodeId=e6bd3213e3e5, content=的风风光光姑姑姑父, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83erHmiaPStHsBjHGm3Y4ZHHanFXRDgAiaEiabOGdC4Q6KfAYrmmuicVyBk7YMJOMXTuQnIpZqReTiceibjdg/132, createdBy=2ab92087896, createdName=陈方郑, createdTime=Mon Jun 04 08:16:49 CST 2018, time=2018-06-04, status=1, ipAttribution=)]
    2018-06-04 陈方郑

    的风风光光姑姑姑父

    0

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