cell综述：阿尔茨海默病30年来的研究进展

2012-04-16 陈蓉生物通

      来自加州大学旧金山分校，Gladstone神经疾病研究所的Lennart Mucke和黄亚东教授发表了题为“Alzheimer Mechanisms and Therapeutic Strategies”的文章，总结概括了过去三十年里，这一疾病的发展，指出这一领域的研究探讨和药物研发，应该多元化发展，来解析阿尔茨海默病这一多因素影响

来自加州大学旧金山分校，Gladstone神经疾病研究所的Lennart Mucke和黄亚东教授发表了题为“Alzheimer Mechanisms and Therapeutic Strategies”的文章，总结概括了过去三十年里，这一疾病的发展，指出这一领域的研究探讨和药物研发，应该多元化发展，来解析阿尔茨海默病这一多因素影响的疾病。

这篇Cell综述【综述全文下载地址Cell.2012-03-16;148(6):1204-22.】指出，对于阿尔茨海默病这一早已被发现的疾病，目前仍然没有有效的方法，能预防，治疗或者逆转阿尔茨海默病患者症状，但是在过去三十年中，这一领域也取得了不少突破性性的进展。

遗传学研究证明这种疾病是由多种因素引发的，跨学科的技术方法——复合生物化学，分子和细胞生物学，以及转基因模型都揭示了其中的分子机制。化学，放射学科，以及系统生物学也开始逐步用于这一疾病的治疗，提供了有效的生物标记，并且个性化医疗方法的出现也有望改变药物研发和临床实验的面貌。

阿尔茨海默病发病机制

作者还指出，由于阿尔茨海默病是一种受到多因素影响的疾病，这一领域的研究探讨和药物研发，应该多元化发展。

>>生物标记

去年5月《Nature Genetics》杂志刊登了这一疾病的重要研究成果：来自英国，德国，美国等多个国家的研究人员组成的研究组剖析了几个与阿尔茨海默病相关的新基因，为深入了解和研究这一疾病提供了重要资料。

这四种与阿尔茨海默病相关的新基因为MS4A、CD2AP、CD33和EPHA1。这项研究是由来自44所美国大学和研究机构的科研人员共同完成的，是迄今涉及科研人员最多的一次关于阿尔茨海默病的研究之一。

在研究中，来自不同大学和研究机构的科研人员将他们各自的研究数据进行了综合对比和分析，所涉及的被调查对象共达5.4万人。研究人员指出，基因研究所取得的成果对今后防治阿尔茨海默病意义重大，研究人员可据此了解这一疾病的起因，并对潜在病人进行甄别，以便在症状尚未出现时就及时采取防治措施。

另外英国，德国等处的研究人员也发表了相似的研究成果，他们发现另外几个与阿尔茨海默病有关的基因：ABCA7, MS4A6A/MS4A4E, EPHA1, CD33和CD2AP。令大家感兴趣的是，这些基因都与胆固醇代谢和炎症有关。

>>药物研究进展

来自美国的科学家们发现一种原先被用于治疗哮喘的药物可以减少β淀粉样蛋白的含量，从而减缓阿尔茨海默病的发展。

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2012-09-24 zhaozhouchifen

#Cell#

41 0
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2012-11-30 维他命

#CEL#

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2013-02-07 12498da4m32(暂无昵称)

#阿尔茨海#

41 0
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2012-05-24 ms1948154235210413

#阿尔茨#

41 0
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2012-04-18 mashirong

#研究进展#

34 0
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2012-04-18 yhj-time

#阿尔茨海默#

32 0

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