CLIN CANCER RES:血小板源Tgfβ1在卵巢癌进展中扮演的角色

2017-09-24 MedSci MedSci原创

转化生长因子β1(Tgfβ1)在肿瘤中扮演着重要角色。绝大部分Tgfβ1来自血小板。CLIN CANCER RES近期发表了一篇文章,研究血小板Tgfβ1在卵巢癌进展中发挥的作用以及这种作用是否仅限与远处转移还是与原发肿瘤生长也有关系。

转化生长因子β1(Tgfβ1)在肿瘤中扮演着重要角色。绝大部分Tgfβ1来自血小板。CLIN CANCER RES近期发表了一篇文章,研究血小板Tgfβ1在卵巢癌进展中发挥的作用以及这种作用是否仅限与远处转移还是与原发肿瘤生长也有关系。

作者比较了血小板特异性Tgfβ1缺陷鼠和野生型鼠鼠源卵巢癌细胞诱导肿瘤的生长情况。利用切除的肿瘤结节研究血小板Tgfβ1对血管生成以及血小板外渗进入肿瘤的影响。为了研究Tgfβ1对不同阶段卵巢癌的影响,作者在注射肿瘤细胞后在不同时间点抑制Tgfβ1受体表达并比较最终的肿瘤大小。研究结果表明,缺少血小板Tgfβ1抑制肿瘤生长,心血管形成和血小板外渗。血小板特异性Tgfβ1缺陷鼠卵巢癌大小不到野生型的一半。在注射后两周内敲低肿瘤细胞Tgfβ1抑制肿瘤生长,在3周后效果不明显。

文章最后认为,在卵巢癌鼠模型中,血小板Tgfβ1促进原发肿瘤生长。在早期阻断Tgfβ1对肿瘤生长的抑制作用更为明显。在卵巢癌治疗过程中阻止血小板活化,脱颗粒以及释放Tgfβ1具有一定治疗意义。

原始出处:
Qianghua Hu,Takeshi Hisamatsu,et al.Role of Platelet-Derived Tgfβ1 in Progression of Ovarian Cancer.CLIN CANCER RES.September 2017 doi:10.1158/1078-0432.CCR-16-3272

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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-10-29 情途末路

    学习了.获益匪浅!感谢分享

    0

  5. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-10-28 情途末路

    学习了.获益匪浅!感谢分享

    0

  6. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-25 luominglian113

    学习了谢谢分享

    0

  7. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 明崖

    学习了.在关注

    0

  8. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 131****1460

    学习了受益匪浅

    0

  9. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 清风拂面

    谢谢分享.学习了

    0

  10. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Sep 24 12:28:35 CST 2017, time=2017-09-24, status=1, ipAttribution=)]
    2017-09-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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