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Oncotarget：缺氧引起的IL-32β增加有利于ROS和缺氧环境下卵巢癌细胞的存活

2017-07-31 Emma MedSci原创

白细胞介素-32卵巢癌细胞PKCδVHL
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研究人员调查了卵巢癌细胞中调控缺氧诱导的IL-32β稳定性的潜在机制。研究显示，IL-32β在氧化应激下减少PKCδ诱导的卵巢癌细胞凋亡，即缺氧引起的IL-32β增加有利于ROS和缺氧环境下的卵巢癌细胞存活。

白细胞介素-32（IL-32）与肿瘤的研究密切相关，PKC家族中的PKCδ对许多类型的细胞起到生长抑制或促凋亡作用，而von Hippel-Lindau（VHL）肿瘤抑制蛋白是泛素介导缺氧诱导因子-1α（HIF-1α）的E3连接酶，能够被蛋白酶体降解。

研究人员调查了卵巢癌细胞中调控缺氧诱导的IL-32β稳定性的潜在机制。研究显示，IL-32β在氧化应激下减少PKCδ诱导的卵巢癌细胞凋亡，即缺氧引起的IL-32β增加有利于ROS和缺氧环境下的卵巢癌细胞存活。

在氧气条件正常的条件下，IL-32β被VHL介导的泛素化降解。与乳腺癌细胞相似，在缺氧条件下卵巢癌细胞的IL-32β表达增加。缺氧或ROS破坏了IL-32β和VHL之间的相互作用，而IL-32β和PKCδ的作用仍继续，导致细胞因子的积累。低氧诱导IL-32β将代谢方式转移到增强的糖酵解途径，IL-32β的表达量由翻译后控制调节，而不是通过转录激活调节。低氧引发PKCδ向内质网或线粒体转位，导致氧化应激诱导的细胞凋亡，但由于缺氧刺激将IL-32β转移向内质网或线粒体，增加的IL-32β与PKCδ相互作用，抑制PKCδ介导的细胞凋亡。

原始出处：
Yong HJ, et al. Von Hippel-Lindau regulates interleukin-32β stability in ovarian cancer cells. Oncotarget. 2017 Jul 17. doi: 10.18632/oncotarget.19311.

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    2018-05-02 仁医06

    #target#

    0

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    2018-05-20 qblt

    #卵巢癌细胞#

    0

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    2017-09-03 psybestwish

    #IL-32#

    0

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    2017-08-02 yxch36

    #癌细胞#

    0

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    2017-08-02 lsndxfj

    #ROS#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1795413, encodeId=70bb1e95413c3, content=<a href='/topic/show?id=248e1e1345b' target=_blank style='color:#2F92EE;'>#target#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17134, encryptionId=248e1e1345b, topicName=target)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed May 02 12:45:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1755465, encodeId=48ba1e55465dc, content=<a href='/topic/show?id=459f368e114' target=_blank style='color:#2F92EE;'>#卵巢癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36871, encryptionId=459f368e114, topicName=卵巢癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f9536903522, createdName=qblt, createdTime=Sun May 20 15:45:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025342, encodeId=c93d202534276, content=<a href='/topic/show?id=89d69663ff' target=_blank style='color:#2F92EE;'>#IL-32#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9663, encryptionId=89d69663ff, topicName=IL-32)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f98e185, createdName=psybestwish, createdTime=Sun Sep 03 16:45:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252315, encodeId=9d351252315ca, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Wed Aug 02 13:45:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364211, encodeId=087e1364211bb, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Wed Aug 02 13:45:00 CST 2017, time=2017-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228925, encodeId=f0c722892596, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Aug 01 21:42:19 CST 2017, time=2017-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=228703, encodeId=630f228e0388, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Tue Aug 01 07:57:00 CST 2017, time=2017-08-01, status=1, ipAttribution=)]
    2017-08-01 doctorJiangchao

    继续学习。

    0

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    2017-08-01 184****9840

    学习了谢谢分享

    0