JAMA Neurol:胖女人小心了,口服避孕药脑静脉血栓形成风险大

2016-03-15 Mechront 译 MedSci原创

近期发表在JAMA Neurology的研究称,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,脑静脉血栓形成(CVT)的风险更大。CVT是一种罕见的疾病,主要影响年轻的成年人和儿童。CVT与静脉血栓栓塞症(VTE)有相同的危险因素如癌症和口服避孕药,此外CVT还有特定的危险因素如局部感染和头部外伤。荷兰阿姆斯特丹学术医疗中心的Jonathan M. Coutinho博士对来自两家医院的

近期发表在JAMA Neurology的研究称,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,脑静脉血栓形成(CVT)的风险更大。

CVT是一种罕见的疾病,主要影响年轻的成年人和儿童。CVT与静脉血栓栓塞症(VTE)有相同的危险因素如癌症和口服避孕药,此外CVT还有特定的危险因素如局部感染和头部外伤。

荷兰阿姆斯特丹学术医疗中心的Jonathan M. Coutinho博士对来自两家医院的CVT患者进行了一项研究,纳入了186例CVT和6,134例对照组。研究者发现,与对照组相比,CVT患者有以下特征:更年轻(40 vs. 48岁)、女性、口服避孕药频率更高、更有可能有癌症既往史。

研究者指出,口服避孕药的肥胖女性,与没有口服避孕药的正常体重女性相比,CVT风险增加近30倍!口服避孕药的超重女性CVT风险同样增加。不过没有使用口服避孕药肥胖人群无论男女,对CVT风险不会产生影响。

由于样本量小,导致了本研究的限制。

作者总结说:“口服避孕药的肥胖女性VTE和CVT的风险如此之高,可能会导致临床医生不愿开具口服避孕药处方给肥胖人群。不过,虽然潜在的相对风险增加了,但是CVT的绝对风险仍很低。不过,口服避孕药会增加意外怀孕风险,进而增加妊娠相关血栓事件的风险。临床上应告知口服避孕药的肥胖人群,其血栓形成风险会增高,尤其是还存在其他危险因素的情况下。这类女性可以选择与血栓形成无关的其他避孕方式如宫内节育器,以避免风险的增加。”

原始出处:

Susanna M. Zuurbier MD, Marcel Arnold MD, PhD,et al.Risk of Cerebral Venous Thrombosis in Obese Women.JAMA Neurology, doi:10.1001/jamaneurol.2016.0001, published online 14 March 2016.


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    2016-04-25 yinhl1978
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    2016-05-17 xue8602
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    2016-11-12 fusion
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    2016-03-21 1de304d2m86(暂无匿称)

    科学减肥

    0

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    2016-03-18 Lisa971

    口服避孕药本身对体重就有增加的作用,体重增加同时也加大脑静脉血栓的风险率。

    0

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    2016-03-16 任然

    瘦,很重要呀

    0

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