心血管

订阅

MedSci主页 / 所有栏目 / 心血管

Am Heart J：高甲状旁腺激素水平增加心血管病事件风险

2013-04-02 欧柏青 译 医学论坛网

甲状旁腺激素水平心血管病事件
关注

　　荷兰学者的一项荟萃研究表明，高甲状旁腺激素（PTH）与心血管病事件风险增加有关，论文2013年3月27日在线发表于《美国心脏杂志》（Am  Heart J）。 　　研究者系统和综合搜索了MEDLINE以及Embase数据库， 查询1947-2012年10月之间以英文发表的有关PTH、心血管事件以及中期预后的前瞻性危险评估研究论文。 　　结果检索了5770篇文章，包含15项研究，研

　　荷兰学者的一项荟萃研究表明，高甲状旁腺激素（PTH）与心血管病事件风险增加有关，论文2013年3月27日在线发表于《美国心脏杂志》（Am  Heart J）。

　　研究者系统和综合搜索了MEDLINE以及Embase数据库， 查询1947-2012年10月之间以英文发表的有关PTH、心血管事件以及中期预后的前瞻性危险评估研究论文。

　　结果检索了5770篇文章，包含15项研究，研究期限为2-14年。所有研究主要在白人中进行，平均年龄55-75岁。荟萃分析共纳入12项研究，其中有10个研究终点包括全部心血管事件，7个研究终点包括致命性心血管事件，3个研究包括非致命性心血管事件。PTH增加与全部心血管事件风险相关：汇集的危险比为1.45，（95%可信区间CI：1.24-1.71）。致命性心血管事件危险比为1.50（95%CI：1.18-1.91），非致命性心血管事件危险比为1.48（95%CI：1.14-1.92）。


Parathyroid hormone and cardiovascular disease events: A systematic review and meta-analysis of prospective studies

Background
Parathyroid hormone (PTH) excess might play a role in cardiovascular health. We therefore conducted a systematic review and meta-analysis to evaluate the association between PTH and cardiovascular disease (CVD) events, and intermediate outcomes.
Methods
We conducted a systematic and comprehensive database search using MEDLINE and Embase between 1947 and October 2012. We included English-language prospective studies that reported risk estimates for PTH and CVD events, and intermediate outcomes. The characteristics of study populations, exposure, and outcomes of total CVD events, fatal and non-fatal CVD events were reported, and a quality assessment was conducted. Results were extracted for the highest versus lowest PTH concentrations, and meta-analyses were carried out using random effects models.
Results
The systematic literature search yielded 5770 articles, and 15 studies were included. Study duration ranged between 2 and 14 years. All studies were performed primarily in whites with a mean age between 55 and 75 years. The meta-analyses included 12 studies, of which 10 investigated total CVD events; 7, fatal CVD events; and 3, non-fatal CVD events. PTH excess indicated an increased risk for total CVD events: pooled HR (95% CI), 1.45 (1.24-1.71). The results for fatal CVD events and non-fatal CVD events were: HR 1.50 (1.18-1.91) and HR 1.48 (1.14-1.92). Heterogeneity was moderately present; however, sensitivity analyses for follow-up duration, prior CVD, or PTH as dichotomous values showed similar results.
Conclusions
The meta-analysis indicates that higher PTH concentrations are associated with increased risk of CVD events.
 

    

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1644366, encodeId=38cb1644366e5, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Apr 15 15:29:00 CST 2013, time=2013-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998292, encodeId=fd871998292b8, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Dec 16 11:29:00 CST 2013, time=2013-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355734, encodeId=4d861355e3450, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452428, encodeId=cad6145242841, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562141, encodeId=09551562141a9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=)]
    2013-04-15 Luyuxie_17

    #血管病#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1644366, encodeId=38cb1644366e5, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Apr 15 15:29:00 CST 2013, time=2013-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998292, encodeId=fd871998292b8, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Dec 16 11:29:00 CST 2013, time=2013-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355734, encodeId=4d861355e3450, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452428, encodeId=cad6145242841, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562141, encodeId=09551562141a9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=)]
    2013-12-16 经常头晕

    #激素水平#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1644366, encodeId=38cb1644366e5, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Apr 15 15:29:00 CST 2013, time=2013-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998292, encodeId=fd871998292b8, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Dec 16 11:29:00 CST 2013, time=2013-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355734, encodeId=4d861355e3450, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452428, encodeId=cad6145242841, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562141, encodeId=09551562141a9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=)]
    2013-04-04 zhaojie88

    #ART#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1644366, encodeId=38cb1644366e5, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Apr 15 15:29:00 CST 2013, time=2013-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998292, encodeId=fd871998292b8, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Dec 16 11:29:00 CST 2013, time=2013-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355734, encodeId=4d861355e3450, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452428, encodeId=cad6145242841, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562141, encodeId=09551562141a9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=)]
    2013-04-04 huperzia

    #甲状旁腺#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1644366, encodeId=38cb1644366e5, content=<a href='/topic/show?id=e3eb89e17fb' target=_blank style='color:#2F92EE;'>#血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89717, encryptionId=e3eb89e17fb, topicName=血管病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64bb23195917, createdName=Luyuxie_17, createdTime=Mon Apr 15 15:29:00 CST 2013, time=2013-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998292, encodeId=fd871998292b8, content=<a href='/topic/show?id=499c6683554' target=_blank style='color:#2F92EE;'>#激素水平#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66835, encryptionId=499c6683554, topicName=激素水平)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f14236, createdName=经常头晕, createdTime=Mon Dec 16 11:29:00 CST 2013, time=2013-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355734, encodeId=4d861355e3450, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452428, encodeId=cad6145242841, content=<a href='/topic/show?id=d90469826e2' target=_blank style='color:#2F92EE;'>#甲状旁腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69826, encryptionId=d90469826e2, topicName=甲状旁腺)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=84ba5566863, createdName=huperzia, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562141, encodeId=09551562141a9, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Apr 04 10:29:00 CST 2013, time=2013-04-04, status=1, ipAttribution=)]
    2013-04-04 slcumt

    #HEART#

    0