Gastroenterology :长期摄入膳食纤维降低克罗恩病发病风险

2013-12-02 吴军 编译 医学论坛网

增加膳食纤维摄入被认为可以降低炎症性肠病(克罗恩病 [CD] 及溃疡性结肠炎[UC])的发病风险。近日,来自美国马萨诸塞州总医院的Ashwin N. Ananthakrishnan等进行了一项前瞻性研究,来明确长期摄入膳食纤维与CD/UC发病率风险之间的关系。研究发现长期摄入膳食纤维(特别来自水果)能降低CD发病风险,但不能降低UC发病风险,需要进一

增加膳食纤维摄入被认为可以降低炎症性肠病(克罗恩病 [CD] 及溃疡性结肠炎[UC])的发病风险。近日,来自美国马萨诸塞州总医院的Ashwin N. Ananthakrishnan等进行了一项前瞻性研究,来明确长期摄入膳食纤维与CD/UC发病率风险之间的关系。研究发现长期摄入膳食纤维(特别来自水果)能降低CD发病风险,但不能降低UC发病风险,需要进一步研究来明确调控相关性的机制。该文发表于近期《胃肠病学》杂志。(Gastroenterology, 2013,145:970-977)【原文下载

研究者收集和分析了来源于“护士健康研究”的170776例女性,随访超过26年;饮食资料通过每4年的半定量食物频率调查量表进行明确,自我报道的CD/UC通过回顾医疗记录进行确认。COX风险比例模型被用来计算风险比(HRs)。

研究者证实269例CD(发生率,8/100000人/年)和338例UC(发生率,10/100000人/年)。与累计平均膳食纤维摄入量的最低百分点相比,膳食摄入量最高百分点(中位-24.3g/天)与降低40%CD风险相关(HR:0.59; 95%可信区间,0.39-0.90),这种显著的降低最主要归功于水果中纤维;来自谷类、粮食或豆荚类的纤维不能改变发病风险;与之相比,全部膳食纤维摄入(HR, 0.82; 95%可信区间,0.58-1.17) 或摄入特殊来源的纤维与UC的发病风险无关。

原文出处

Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, Fuchs CS, Willett WC, Richter JM, Chan AT.A Prospective Study of Long-term Intake of Dietary Fiber and Risk of Crohn's Disease and Ulcerative Colitis.Gastroenterology. 2013 Nov;【原文下载

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    2014-01-18 许安
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    2013-12-04 zhaojie88
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