Lab Chip:郑海荣团队在超声神经调控方面取得新进展

2017-05-25 佚名 深圳先进技术研究院

日前,中国科学院深圳先进技术研究院医工所郑海荣团队在超声神经调控方面取得新进展。相关研究成果Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves发表在Lab on a chip杂志上,并被选为当期的封面文章。近些年,神经精

日前,中国科学院深圳先进技术研究院医工所郑海荣团队在超声神经调控方面取得新进展。相关研究成果Ultrasound neuro-modulation chip: activation of sensory neurons in Caenorhabditis elegans by surface acoustic waves发表在Lab on a chip杂志上,并被选为当期的封面文章。

近些年,神经精神疾病广泛发生,利用物理方法调控特定核团是治疗、干预神经精神疾病的一种切实可行的方法。超声作为一种机械波,可无创刺激颅内深部脑区,作为一种非侵入的神经调控手段受到越来越多的关注。由于超声物理效应复杂,包括机械效应、热效应等,目前超声神经调控的机制尚不清楚。

研究人员设计制备了一种新型的超声神经刺激芯片,以经典模式生物秀丽隐杆线虫作为研究对象。研究结果表明,在超声作用下,线虫多模感受神经元ASH会被超声激活,产生回避的行为学反应。同时,感知温度的AFD神经元并不会被超声激活,这表明线虫的回避行为主要是超声波机械效应引起的,Tax-4突变体实验进一步验证了该结果。

此项工作的意义在于提出了一种新型的超声神经调控器件,该器件可以和钙成像、膜片钳等生物学手段相兼容,实现对超声神经调控机制的研究,从而为超声神经调控治疗神经类疾病提供基础和理论依据。

上述研究工作得到国家自然科学基金委国家重大科研仪器研制项目、广东省杰青项目以及深圳市学科布局等多个项目支持。

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    2017-05-27 往日如昨

    学习了谢谢分享

    0

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    2017-05-27 meiliwuxian

    新方向

    0

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    2017-05-26 meiliwuxian

    超声应用前途无量

    0

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    2017-05-25 有备才能无患

    超声作为一种机械波,可无创刺激颅内深部脑区,作为一种非侵入的神经调控手段受到越来越多的关注。

    0

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    2017-05-25 林3301

    医学不断前进

    0

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    2017-05-25 Chongyang Zhang

    签到学习了很多。

    0

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    2017-05-25 solarjin

    学习了新知识,谢谢梅斯医学

    0

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    2017-05-25 忠诚向上

    好好努力学习

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    2017-05-25 Drhzm308

    厉害,医学的发展离不开其他行业的进步

    0

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