Int J Cancer：放射性碘治疗甲状腺癌女性，几乎不影响未来的生育能力

2017-08-31 MedSci MedSci原创

放射性碘治疗（ radioactive iodine ，RAI）是指口服一定量的131碘后，因为甲状腺细胞对碘化物具有特殊的亲和力，所有碘131能被甲状腺大量吸收，具有损害作用的放射131碘能种入甲状腺组织中，131碘在衰变为131氙时，能放射出β射线(占99%)和γ射线(占1%)。前者的有效射程仅有0.5～2毫米，能选择性地破坏甲状腺腺泡上皮而不影响邻近组织，甲状腺组织能受到长时间的集中照射，其

放射性碘治疗（radioactive iodine ，RAI）是指口服一定量的131碘后，因为甲状腺细胞对碘化物具有特殊的亲和力，所有碘131能被甲状腺大量吸收，具有损害作用的放射131碘能种入甲状腺组织中，131碘在衰变为131氙时，能放射出β射线(占99%)和γ射线(占1%)。前者的有效射程仅有0.5～2毫米，能选择性地破坏甲状腺腺泡上皮而不影响邻近组织，甲状腺组织能受到长时间的集中照射，其腺体被破坏后逐渐坏死，代之以无功能的结缔组织，达到类似甲状腺次全切除手术的目的。

放射性碘治疗分化型甲状腺癌与女性性腺功能的改变有关，包括月经功能的改变和绝经年龄的提前。本研究中，研究人员评估了RAI与15-39岁时诊断为甲状腺癌的幸存者在诊断后的活胎出生率之间的相关性。

2000年1月-2013年12月间，在北卡罗莱纳中央癌症登记处（CCR）登记的诊断为分化型甲状腺癌的女性被纳入了本研究。通过CCR记录与州立出生证明文件来识别甲状腺癌症幸存者的活胎生产情况。随访的患者-年从诊断后6个月开始累计至第一胎活产、46岁生日、死亡或2014年12月31日。研究人员使用Cox比例风险回归估计的第一胎活产的危险比（HR）和95%置信区间（CI）。

研究人员发现，在2360例分化型甲状腺癌的女性中，有53%的患者接受了RAI治疗。在随访结束（最大14.5年）时，在接受RAI治疗和未接受RAI治疗的患者中，活胎生产的累积发病率分别为30和29.3%。总的来说，第一胎活产率在各组间并没有显著不同（HR = 1.00；95%CI：0.82，1.23）。

本研究的观察队列发现，放射性碘治疗与出生率降低无关。这个发现增加了甲状腺癌对未来生育力的影响较小的证据。

原始出处：

Anderson C, Engel SM,et al.Birth rates after radioactive iodine treatment for differentiated thyroid cancer.Int J Cancer. 2017 Aug 9. doi: 10.1002/ijc.30917. [Epub ahead of print]

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2018-03-19 redcrab

#放射性碘治疗#

29 0
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2017-09-17 KO229256262

学习了.加油

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2017-09-12 虈亣靌

好好看下.内容丰富

55 0
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2017-09-08 1e183db5m33(暂无匿称)

增加了知识面.谢谢.

62 0
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2017-09-04 虈亣靌

学习了.谢谢作者分享!

54 0
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2017-09-02 天涯183

非常好的文章.学习了

47 0
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2017-09-02 仁医06

#放射性碘#

34 0
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2017-09-02 flysky120

学习一下知识

20 0
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2017-09-02 luominglian113

学习了.谢谢分享

25 0
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2017-09-01 tanxingdoctor

学习啦!谢谢分享!

22 0