Am J Gastroenterol:结直肠息肉体积与组织病理学特征

2017-12-13 zhangfan MedSci原创

研究认为结肠息肉的体积与其组织病理学特征存在显著相关性,而超过1/4的10mm以下息肉存在晚期组织病理学特征

尽管结直肠大息肉相对于小息肉癌变风险更高,但息肉大小与组织类型之间的关系尚未明确阐明。近日研究人员考察了息肉体积与不同息肉组织学类型之间的关系。

研究人员对美国Miraca生命科学数据库资料进行考察,提取了483998名结肠镜息肉切除患者资料,共550811例息肉信息。将息肉进一步分型包括增生性息肉(HP)、管状腺瘤(TA)、管形绒毛状腺瘤(TVA)、无蒂锯齿状腺瘤/息肉以及腺癌。

在所有息肉组织中,81%息肉体积为1-9mm,而103517例(19%)体积超过10mm。550811例息肉中,仅18591例(3.4%)具有晚期腺瘤的组织学特征(TVA, 高度异型增生或癌症),其中25%为1-9mm息肉,75%为10mm以上息肉。1-5mm息肉具有晚期腺瘤的组织学特征比例为0.6%,而6-9mm息肉具有晚期腺瘤的组织学特征比例为2.1%,10mm以上息肉的具有晚期腺瘤的组织学特征比例为13.4%。增生性息肉的比例随息肉体积的增大而降低,而管状腺瘤发病率与息肉体积无关。

研究认为结肠息肉的体积与其组织病理学特征存在显著相关性,而超过1/4的10mm以下息肉存在晚期组织病理学特征。

原始出处:

Kevin O Turner DO et al. Lesions of All Types Exist in Colon Polyps of All Sizes.Am J Gastroenterol. 12 December 2017.

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    2018-05-25 许安
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    2017-12-15 jktdtl
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    2017-12-13 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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