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Nature Communications：Tempol通过改变肠道微生物群降低肥胖

2013-10-15 佚名 Nature Communication

肠道微生物群肥胖
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9月24日，Nature Communications上发表的一篇论文提出，抗氧化剂Tempol通过改变小肠微生物群来降低小鼠的肥胖。这项研究提出了肠道微生物群在药物作用和体重调控中都有所涉及的另一个例子，同时也揭示了小肠中一个可能会被证明是减肥药物有用目标的信号通道。【原文下载】 Frank Gonzalez及同事用Tempol对小鼠进行处理，并在小肠里的主要微生物群中检测到一个变化。这一变化

9月24日，Nature Communications上发表的一篇论文提出，抗氧化剂Tempol通过改变小肠微生物群来降低小鼠的肥胖。这项研究提出了肠道微生物群在药物作用和体重调控中都有所涉及的另一个例子，同时也揭示了小肠中一个可能会被证明是减肥药物有用目标的信号通道。【原文下载】

Frank Gonzalez及同事用Tempol对小鼠进行处理，并在小肠里的主要微生物群中检测到一个变化。这一变化导致在与牛磺酸共轭的胆汁酸降解中所涉及的一种微生物酶的活性降低，同时小肠中的胆汁酸水平在处理过程中相应提高。与牛磺酸共轭的胆汁酸已知会降低FXR信号作用，后者是在胆汁酸、脂质和葡萄糖代谢中所涉及的一个通道。虽然尚不清楚Tempol对人类肥胖或肠道微生物群是否会有任何效应，但这项研究为解释Tempol怎样影响小鼠的肥胖提供了一个可能的机制，同时也表明FXR信号作用通道可能是治疗代谢病的一个合适的目标。

原文检索

Li F, Jiang C, Krausz KW, Li Y, Albert I, Hao H, Fabre KM, Mitchell JB, Patterson AD, Gonzalez FJ.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.Nat Commun. 2013 Sep 24;4:2384.【原文下载】

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    2014-05-04 wjcjjian

    #微生物#

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    2014-07-26 liye789132251

    #Nat#

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    2013-12-01 liuli5079

    #COMMUN#

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    2013-10-17 yangjxjc

    #肠道微生物群#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1824562, encodeId=54df182456267, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun May 04 19:57:00 CST 2014, time=2014-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879692, encodeId=030618e969203, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jul 26 04:57:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086650, encodeId=873b208665019, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Dec 01 23:57:00 CST 2013, time=2013-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298823, encodeId=8a8112988231a, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367717, encodeId=f761136e71731, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573387, encodeId=6a1b15e338739, content=<a href='/topic/show?id=28f4125430b' target=_blank style='color:#2F92EE;'>#Nature Communications#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12543, encryptionId=28f4125430b, topicName=Nature Communications)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bea15872676, createdName=qindq, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575057, encodeId=9f2915e505778, content=<a href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=)]
    2013-10-17 zhu_jun9837

    #微生物群#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1824562, encodeId=54df182456267, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun May 04 19:57:00 CST 2014, time=2014-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879692, encodeId=030618e969203, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jul 26 04:57:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086650, encodeId=873b208665019, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Dec 01 23:57:00 CST 2013, time=2013-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298823, encodeId=8a8112988231a, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367717, encodeId=f761136e71731, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573387, encodeId=6a1b15e338739, content=<a href='/topic/show?id=28f4125430b' target=_blank style='color:#2F92EE;'>#Nature Communications#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12543, encryptionId=28f4125430b, topicName=Nature Communications)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bea15872676, createdName=qindq, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575057, encodeId=9f2915e505778, content=<a href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=)]
    2013-10-17 qindq

    #Nature Communications#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1824562, encodeId=54df182456267, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun May 04 19:57:00 CST 2014, time=2014-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879692, encodeId=030618e969203, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jul 26 04:57:00 CST 2014, time=2014-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2086650, encodeId=873b208665019, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Dec 01 23:57:00 CST 2013, time=2013-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298823, encodeId=8a8112988231a, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367717, encodeId=f761136e71731, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573387, encodeId=6a1b15e338739, content=<a href='/topic/show?id=28f4125430b' target=_blank style='color:#2F92EE;'>#Nature Communications#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12543, encryptionId=28f4125430b, topicName=Nature Communications)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6bea15872676, createdName=qindq, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575057, encodeId=9f2915e505778, content=<a href='/topic/show?id=6f66121e89e' target=_blank style='color:#2F92EE;'>#MPO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12178, encryptionId=6f66121e89e, topicName=MPO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b9016060451, createdName=风铃826, createdTime=Thu Oct 17 00:57:00 CST 2013, time=2013-10-17, status=1, ipAttribution=)]
    2013-10-17 风铃826

    #MPO#

    0