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J Am Acad Dermatol：头颈部皮肤恶性黑色素瘤研究

2016-08-25 Moon 译 MedSci原创

头颈部皮肤恶性黑色素瘤
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大多数头颈部皮肤恶性黑色素瘤(CHNM)的研究表明，CHNM与其他部位黑色素瘤相比，生存更差，尤其是头皮或颈部的黑色素瘤。 我们试图比较CHNM和躯干和四肢皮肤黑色素瘤患者和肿瘤特征，以及CHNM不同部位（面/耳朵 vs 头皮/颈部；前 vs 后）患者和肿瘤特征，还有CHNM患者的预后因素。 研究纳入了2008-2012年在挪威诊断为皮肤黑色素瘤患者（n=8120）中的所有CHNM (

大多数头颈部皮肤恶性黑色素瘤(CHNM)的研究表明，CHNM与其他部位黑色素瘤相比，生存更差，尤其是头皮或颈部的黑色素瘤。

我们试图比较CHNM和躯干和四肢皮肤黑色素瘤患者和肿瘤特征，以及CHNM不同部位（面/耳朵 vs 头皮/颈部；前 vs 后）患者和肿瘤特征，还有CHNM患者的预后因素。

研究纳入了2008-2012年在挪威诊断为皮肤黑色素瘤患者（n=8120）中的所有CHNM (n = 1074)患者。

与躯干和四肢皮肤黑色素瘤患者相比，CHNM患者更多见于男性，更有可能出现结节性和雀斑恶性皮肤黑色素瘤，并较高的T分期诊断风险更高(P ≤ .01)。后位CHNM与前位相比，有更高的T分期诊断，更可能诊断为溃疡和晚期阶段(P < .001)。多因素分析显示，T分期和临床分期是影响黑色素瘤特异性和整体死亡的唯一重要预后因素(P < .001)。

样本量小和相对高的丢失率是本研究的限制之一。

后位CHNM与前位相比，晚期CHNM风险更高；但多因素分析中，黑色素瘤部位与黑色素瘤特异性和整体死亡无关。

原始出处：

Helsing P, et al. Cutaneous head and neck melanoma (CHNM): A population-based study of the prognostic impact of tumor location.J Am Acad Dermatol. 2016;doi:10.1016/j.jaad.2016.06.048.

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    2016-10-24 lishizhe

    #ACA#

    0

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    2017-07-10 sunylz

    #色素#

    0

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    2016-09-01 虈亣靌

    学习了，非常好

    0

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    2016-08-30 李东泽

    很好，不错，以后会多学习

    0

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    2016-08-29 zibozhouping

    新理念，值得重视！学习

    0

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    2016-08-27 wshxjq

    #头颈部#

    0

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    2016-08-27 cqlidoudou

    #黑色素#

    0

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    2016-08-27 柳叶一刀

    #黑色素#

    0

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    2016-08-27 木头人519

    #颈部#

    0

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