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JAMA：长期肥胖或增冠状动脉钙化风险

2013-07-24 姜珊 中国医学论坛报

增冠状动脉钙化肥胖
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美国一项研究表明，全身性或腹型肥胖持续时间较长，与中年期亚临床冠心病及其进展相关，且这一相关性不依赖于肥胖程度。成年早期预防或至少延迟肥胖的发生，可能降低中年期动脉粥样硬化风险。论文7月17日发表于《美国医学会杂志》[JAMA 2013，310（3）：280]。 研究纳入3275名18~30岁成人，基线时均无全身性肥胖[体质指数（BMI）≥30]或腹型肥胖[腰围（WC）：男性＞102&

美国一项研究表明，全身性或腹型肥胖持续时间较长，与中年期亚临床冠心病及其进展相关，且这一相关性不依赖于肥胖程度。成年早期预防或至少延迟肥胖的发生，可能降低中年期动脉粥样硬化风险。论文7月17日发表于《美国医学会杂志》[JAMA 2013，310（3）：280]。

研究纳入3275名18~30岁成人，基线时均无全身性肥胖[体质指数（BMI）≥30]或腹型肥胖[腰围（WC）：男性＞102 cm，女性＞88 cm]。在随访的第15、20或25年，参与者接受CT扫描以检查有否冠状动脉钙化（CAC）。在随访的第2、5、7、10、15、20和25年，重复测量BMI及WC，以计算全身性和腹型肥胖持续时间。

结果为，随访期间分别有40.4%和41.0%的参与者发展为全身性或腹型肥胖。与无肥胖者相比，肥胖超过20年者CAC发生率较高，且肥胖者中约25.2%和27.7%出现CAC进展，而不肥胖者中分别有20.2%和19.5%出现CAC进展。校正BMI 或WC及潜在混杂因素后，全身性或腹型肥胖每延长1年，CAC风险比（HR）分别为1.02和1.03，CAC进展的校正比值比（OR）均为1.04。进一步校正随访期间潜在的中间代谢因素后，相关性减弱但在很大程度上仍然存在。

Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, Terry JG, Liu K.Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age.JAMA. 2013 Jul 17;310(3):280-8. doi: 10.1001/jama.2013.7833.PMID:23860986

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    2014-04-14 夏天与十三菇凉

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    2014-01-03 1249897bm45(暂无昵称)

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    2013-07-26 shizhenshan

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