内镜下小凹陷型胃癌的诊断

2019-01-20 青海涛 消化专家青海涛大夫

放大内镜是诊断凹陷型小胃癌的主要手段,但也存在诊断困难病例

放大内镜是诊断凹陷型小癌的主要手段,但也存在诊断困难病例

基于许多研究,很明显放大窄带成像(NBI)对癌的准确诊断是有用的——即使是对小的、凹陷的黏膜内胃癌。据报道,幽门螺杆菌根除治疗改变了胃癌,包括胃癌和腺瘤的宏观外观。由于胃癌边界模糊和/或缺乏明显的癌变特征,即使通过放大NBI内镜也难以诊断根除幽门螺杆菌后的胃癌。其原因可能是胃癌组织表面常覆盖有低异型度上皮或非肿瘤性上皮;此外,在根除幽门螺杆菌后的一系列胃癌中,44%的除菌后胃癌表面结构呈“胃样”外观。除菌后胃癌的特点是:病灶小,位置在胃的非贲门区、凹陷型、组织学为分化型。

放大内镜价格昂贵,现状是不可能所有的医院都配备放大内镜

最近有报道称,放大蓝激光成像(magnifying blue laser imaging, BLI)是一种新型的图像增强内镜(image-enhanced endoscopy, IEE)模式,其对早期胃癌的诊断效果优于传统的白光成像内镜,放大BLI的诊断效果被描述为类似于放大NBI 。然而,虽然广泛使用配备有NBI和BLI的内窥镜系统,但是只有有限数量的病例需要进行放大的NBI/BLI内镜检查,即使在专门从事胃肠病学的医院中也是如此。因此,许多内镜医师可能正在使用没有放大功能的常规非放大(NM)——NBI/BLI内镜来筛选早期胃癌。 

如何通过非放大内镜来诊断早期小胃癌?最近发表在Endosc Int Open. 2018 Dec; 6(12): E1445–E1453的文献做了相关研究。



常规非放大NBI/BLI内镜下小凹陷型胃癌的内镜特征——两个“指数”

1、NBI/BLI指数:胃癌/良性凹陷病灶区域的平均灰度值与病灶周围区域的平均灰度值的比率。

2、c指数:是整个病变的整体不规则形状,而不是病变边缘的局部不规则形状。完全圆的c指数值为1;当形状偏离完全圆时,c指数值减小。



3、NBI/BLI指数:对比周围的区域,胃癌中的凹陷区域是相对明亮的颜色。

4、c指数:胃癌的形状比良性凹陷病灶更圆。

通常,早期凹陷型胃癌,尤其是分化型腺癌,呈现微红和不规则形状的凹陷。虽然不规则边缘,即在凹陷症边缘的棘样外观是凹陷型胃癌的预测指标,在该研究中评估的c指数表明整个病变的不规则形状而不仅仅是其边缘。



幽门螺杆菌感染的胃癌的代表性非放大NBI图像。 凹陷区域比周围区域更亮。NBI/BLI指数和c指数分别为1.11和0.81。



幽门螺杆菌根除后的代表性胃癌病例。 与周围区域相比,凹陷区域是相对明亮的区域。NBI/BLI指数和c指数分别为1.26和0.86。

NBI/BLI指数可能用于人工智能

由于根除幽门螺杆菌成功后早期胃癌的诊断即使用NBI/BLI进行放大内镜检查,也不一定令人满意,因此该诊断策略可能是合适的。虽然不可否认,放大NBI/BLI是在胃癌诊断中发现不规则微血管和微表面模式的重要方式,但NBI/BLI指数反映了微血管和微表面特征“混合整体图像“。在日常内窥镜检查中,我们经常发现凹陷病变,偶尔会出现多处凹陷病变。因此,NBI/BLI指数可能提供有关人工智能(AI)未来使用的有用信息,包括计算机辅助/基于计算机的诊断和深度学习,用于胃癌的检测和诊断。

结语

总之,在非放大IEE图像中由NBI/BLI和C指数可以提升较小凹陷病变的检出,对于较亮颜色和较圆形状的病变进行活组织检查明确诊断。

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    2019-03-08 jyzxjiangqin

    内镜下小凹陷胃癌的诊断。

    0

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    2019-02-20 jyzxjiangqin

    内镜下小凹陷型胃癌的诊断。

    0

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    2019-02-13 jyzxjiangqin

    内镜下小凹陷型胃癌的诊断。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2058985, encodeId=c3362058985bc, content=<a href='/topic/show?id=e9f38324118' target=_blank style='color:#2F92EE;'>#胃癌的诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83241, encryptionId=e9f38324118, topicName=胃癌的诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Fri Nov 22 21:22:00 CST 2019, time=2019-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362265, encodeId=4cb936226584, content=内镜下小凹陷胃癌的诊断。, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Mar 08 17:54:32 CST 2019, time=2019-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361073, encodeId=0a513610e3db, content=内镜下小凹陷型胃癌的诊断。, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Feb 20 06:53:57 CST 2019, time=2019-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360506, encodeId=fe1136050601, content=内镜下小凹陷型胃癌的诊断。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Feb 13 06:52:59 CST 2019, time=2019-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359755, encodeId=2689359e5596, content=内镜下小凹陷型胃癌的诊断。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri Feb 01 19:24:40 CST 2019, time=2019-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359568, encodeId=aa83359568a0, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jan 30 11:11:14 CST 2019, time=2019-01-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358974, encodeId=bdea3589e4f3, content=内镜下小凹陷型胃癌。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jan 23 07:00:32 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1262047, encodeId=75c2126204e82, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Tue Jan 22 02:22:00 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358704, encodeId=0c78358e048b, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sun Jan 20 11:33:53 CST 2019, time=2019-01-20, status=1, ipAttribution=)]
    2019-02-01 jyzxjiangqin

    内镜下小凹陷型胃癌的诊断。

    0

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    2019-01-30 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2019-01-23 jyzxjiangqin

    内镜下小凹陷型胃癌。

    0

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    2019-01-20 1dd8a7c5m95(暂无匿称)

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

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