Gut:日常饮食结构对肠易激患者肠道菌群的影响

2017-04-21 zhangfan MedSci原创

低聚糖、双糖、单糖和多元醇餐饮食通过改变肠道菌群分布对粪便细菌有显着影响

肠道细菌对人们健康的重要性毋庸置疑,但每天的饮食对肠道细菌的影响尚不是十分清楚。近日,研究人员对不同的饮食结构对肠道细菌的影响开展研究。

研究招募了67名肠易激综合征患者随机进入对照组(n=34)或低聚糖、双糖、单糖和多元醇餐饮组(FODMAPs, n=33),研究持续4周。分别在试验开始前(基线)后纪录粪便样本和IBS症状严重度评分(IBS-SSS)。粪便菌群失调试验(GA-map Dysbiosis Test) 用于评估细菌组成。试验认定IBS-SSS评分减少50分以上视为有应答。

研究发现,FODMAPs组存在应答,但对照组无变化;试验开始前粪便样本,FODMAPs组与对照组差别显着;相比于FODMAPs组有应答患者,FODMAPs组无应答患者细菌丰度在饮食干预后显着提高;有42%的FODMAPs组患者粪便菌群失调试验得分提高,对照组有33%的患者得分降低,FODMAPs组无应答患者较有应答患者的得分较基线变化大。对照组患者菌群改变不显著,FODMAPs组双歧杆菌和放线菌数量减少。

研究表明低FODMAP饮食通过改变肠道菌群分布对粪便细菌有显著影响。

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    2017-04-26 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2017-04-21 明月清辉

    谢谢分享,学习了

    0

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    2017-04-21 1ddf0692m34(暂无匿称)

    涨知识,学习了

    0