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Cancer Res：清华大学郭伟课题组揭示临床肺肿瘤干细胞的自我更新与耐药机制

2017-04-26 佚名 生物帮

肺肿瘤干细胞耐药机制
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日前，国际著名肿瘤学杂志《Cancer Research》上在线发表了清华大学医学院郭伟课题组题为《NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer》(NOTCH1信号通路调控非小细胞肺肿

日前，国际著名肿瘤学杂志《Cancer Research》上在线发表了清华大学医学院郭伟课题组题为《NOTCH1 signaling regulates self-renewal and platinum chemoresistance of cancer stem-like cells in human non-small cell lung cancer》(NOTCH1信号通路调控非小细胞肺肿瘤干细胞的自我更新与耐药)的研究文章。南京医科大学联合培养张赟博士、清华医学院博士生徐伟、协和医院郭慧琴教授是文章的共同第一作者。

研究建立了原创的临床肿瘤研究技术(patient-derived Cells and xenograft models)，分离出新颖的肺肿瘤干细胞、并揭示了这些细胞自我更新与化疗耐药的机制。基于发现，提出了新的解决肺癌化疗耐药的治疗策略。肿瘤干细胞被认为是肿瘤发生、转移、耐药和复发的关键根源之一。以上新技术和发现是对精准医疗的重要贡献。

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    2017-06-12 夏天与十三菇凉

    #肺肿瘤#

    0

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    2017-05-01 xsm926

    #自我更新#

    0

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    2017-10-31 zhaozuguo

    #耐药机制#

    0

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    2017-04-28 医生2397

    #清华#

    0

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    2017-04-27 doctorJiangchao

    研究干细胞实在困难 赞一个

    0

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    2017-04-26 明月清辉

    谢谢分享，学习了

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