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2021 年侵袭性曲霉病诊断和管理共识指南

2021-12-22 澳大利亚皇家医师学院 Internal Medicine Journal

曲霉病侵袭性曲霉病染病组

血液学/肿瘤学患者的侵袭性曲霉病 (IA) 表现为原发性感染或突破性感染，可能对抗真菌治疗无效，并且相关死亡率很高。

中文标题：

2021 年侵袭性曲霉病诊断和管理共识指南

英文标题：

Consensus guidelines for the diagnosis and management of invasive aspergillosis, 2021

发布机构：

澳大利亚皇家医师学院

发布日期：

2021-12-22

简要介绍：

血液学/肿瘤学患者的侵袭性曲霉病 (IA) 表现为原发性感染或突破性感染，可能对抗真菌治疗无效，并且相关死亡率很高。其他新出现的患者风险组包括重症监护室中患有严重呼吸道病毒感染的患者，包括 COVID-19。鉴于自 2014 年之前的指南以来的知识进步，这些指南提出了关键的诊断和治疗建议。基于培养和组织学的方法仍然是 IA 诊断的核心。越来越多的证据表明，使用真菌生物标志物的非培养方法可用于先发制人的感染筛查，以及联合使用时用于 IA 诊断。尽管唑类耐药在澳大利亚似乎并不常见，但临床药敏试验推荐使用烟曲霉复合分离物。伏立康唑仍然是治疗原发性 IA（包括肺外疾病）的首选一线抗真菌药物。儿科治疗的建议大致遵循成人的建议。对于突破性和难治性 IA，强烈建议改变抗真菌药物的类别，并且可能需要考虑临床试验中的药物。更新的基于免疫学的成像方式值得进一步研究，而对 IA 和抗真菌耐药性的监测对于告知当前治疗建议的相关性仍然至关重要。

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    2024-03-21 1469ad48m51暂无昵称 来自山西省

    学习了

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    2024-02-06 13816676933_24061067 来自上海

    学习学习

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    2022-04-21 145dcc50m70暂无昵称

    #学习#学习学习

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    2022-04-21 145dcc50m70暂无昵称

    ***

    0

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    2022-03-08 genglihui01

    学习了

    0

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