印度国家研究协会关于急性肝衰竭的肝病共识声明(第1部分):流行病学,发病机制,表现和预后

2020-10-05 J Clin Exp Hepatol . Jul-Aug 2020;10(4):339-376

急性肝功能衰竭(ALF)是由多种病因引起的罕见,不可预测,可能致命的急性肝损伤(ALI)并发症。文献报道的ALF病因存在地区差异,这会影响临床表现和自然病程。在旨在反映印度临床实践的共识文章的这一部分

中文标题:

印度国家研究协会关于急性肝衰竭的肝病共识声明(第1部分):流行病学,发病机制,表现和预后

英文标题:

Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis

发布机构:

发布日期:

2020-10-05

简要介绍:

急性肝功能衰竭(ALF)是由多种病因引起的罕见,不可预测,可能致命的急性肝损伤(ALI)并发症。文献报道的ALF病因存在地区差异,这会影响临床表现和自然病程。在旨在反映印度临床实践的共识文章的这一部分中,讨论了疾病负担,流行病学,临床表现,监测和预后。在印度,病毒性肝炎是导致ALF的最常见原因,而由于抗结核药引起的药物性肝炎是第二大最常见的原因。 ALF的临床表现以黄疸,凝血病和脑病为特征。将ALF与其他肝衰竭原因区分开来非常重要,包括急性肝衰竭,亚急性肝衰竭以及某些可以模仿这种表现的热带感染。该病通常具有很高的临床病程,短期死亡率高。死亡通常可归因于脑部并发症,感染以及由此导致的多器官功能衰竭。及时进行肝移植(LT)可以改变结局,因此,在可以安排LT之前为患者提供重症监护至关重要。评估预后以选择适合LT的患者同样重要。已经提出了几种预后评分,它们的比较表明,本地开发的动态评分比西方世界描述的评分要高。 ALF的管理将在本文档的第2部分中进行描述。

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    2021-03-26 1771e91b86m

    /∩丶

    0

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    2021-03-26 1771e91b86m

    非常好

    0

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    2020-12-04 想吃柚子

    专业性强!

    0