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B7-1 and GM-CSF enhance the anti-tumor immune effect of DC-tumor fusion vaccine in the treatment of prostate cancer

期刊: MEDICAL ONCOLOGY, 2020; 37 (11)

The treatment of castration-resistant prostate cancer (CRPC) is always a difficulty in the clinic. Most patients with localized tumor eventually devel......

Back to (new) normality-A CODRAL/AIRO-L survey on cancer radiotherapy in Lombardy during Italian COVID-19 phase 2

期刊: MEDICAL ONCOLOGY, 2020; 37 (11)

Background Italy experienced one of the world's severest COVID-19 outbreak, with Lombardy being the most afflicted region. However, the imposed safety......

Association between the CEBPA and c-MYC genes expression levels and acute myeloid leukemia pathogenesis and development

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

CEBPA and c-MYC genes belong to TF and play an essential role in hematologic malignancies development. Furthermore, these genes also co-regulate with ......

Primary evaluation of an air-cooling device to reduce oral mucositis: a pilot study in healthy volunteers

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

Oral mucositis is a common side effect of chemo and radiotherapy causing painful ulcers in the oral mucosa. One of the preventive treatments recommend......

Impact of preexisting antinuclear antibodies on combined immunotherapy and chemotherapy in advanced non-small cell lung cancer patients

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

Combined immunotherapy and chemotherapy is a promising standard treatment in patients with advanced non-small cell lung cancer (NSCLC). This study aim......

Hypomethylated SPANXA1/A2 promotes the metastasis of head and neck squamous cell carcinoma

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

The aberrant expression of SPANXA1/A2 (sperm protein associated with the nucleus on the X-chromosome, family members A1/A2) has been observed in multi......

Iron overload is related to muscle wasting in patients with cachexia of gastric cancer: using quantitative proteome analysis

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

The incidence of gastric cancer cachexia is high and the clinical management is poor, so the study aimed to clarify the mechanism of muscle wasting to......

Carboxyl-terminal polypeptide fragment of MUC16 combing stathmin1 promotes gallbladder cancer cell migration and invasion

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

CA-125, coded by MUC16 gene, is responsible to many kinds of tumor metastasis. However, the related mechanism remains unclear. We have established a n......

Mitotic checkpoint kinase Mps1/TTK predicts prognosis of colon cancer patients and regulates tumor proliferation and differentiation via PKC alpha/ERK1/2 and PI3K/Akt pathway

期刊: MEDICAL ONCOLOGY, 2020; 37 (1)

Mps1/TTK plays an important role in development of many tumors. The purpose of the present study was designed to investigate the role of TTK in colon ......

The role of vascular endothelial growth factor in the hypoxic and immunosuppressive tumor microenvironment: perspectives for therapeutic implications

期刊: MEDICAL ONCOLOGY, 2020; 37 (1)

The microvasculature and immune cells are major components of the tumor microenvironment (TME). Hypoxia plays a pivotal role in the TME through hypoxi......

Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation

期刊: MEDICAL ONCOLOGY, 2020; 37 (1)

Background We previously showed that cobalt chloride (CoCl2) induction of polyploid giant cancer cells (PGCCs) was characterized by abnormal cell cycl......

Inhibition of PI3K/AKT/mTOR and MAPK signaling pathways decreases progranulin expression in ovarian clear cell carcinoma (OCCC) cell line: a potential biomarker for therapy response to signaling pathway inhibitors

期刊: MEDICAL ONCOLOGY, 2020; 37 (1)

Patients with advanced stage ovarian clear cell carcinoma (OCCC) have a poor prognosis due to resistance to conventional platinum chemotherapy. Recent......

Proteasome inhibitors attenuates mitoxantrone-triggered immunogenic cell death in prostate cancer cells

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

Both mitoxantrone (MTX) and proteasome inhibitors efficiently trigger immunogenic cell death (ICD) in cancer cells. However, whether the combination o......

c-Met/MAPK pathway promotes the malignant progression of residual hepatocellular carcinoma cells after insufficient radiofrequency ablation

期刊: MEDICAL ONCOLOGY, 2020; 37 (12)

Radiofrequency ablation (RFA) is popularly used in the treatment of hepatocellular carcinoma (HCC). However, the accelerated malignant progression of ......

Ketogenic diets in medical oncology: a systematic review with focus on clinical outcomes

期刊: MEDICAL ONCOLOGY, 2020; 37 (2)

Preclinical data provide evidence for synergism between ketogenic diets (KDs) and other oncological therapies. The aim of this systematic review was t......

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