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Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (1)

Information regarding deaths caused by poisoning or adverse effects of medication in Danish persons not using illicit narcotic drugs (PNUIDs) is spars......

Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin-induced pulmonary fibrosis in mice

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (2)

The purpose of this study was to explore the protective effect and potential mechanism of berberine on bleomycin (BLM)-induced fibrosis after lung inj......

The adhesion G protein-coupled receptor GPR56/ADGRG1 in cytotoxic lymphocytes

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 133 (4)

GPR56/ADGRG1 is an adhesion G protein-coupled receptor connected to brain development, haematopoiesis, male fertility, and tumorigenesis. Nevertheless......

Predictors of older patients' willingness to have medications deprescribed: A cross-sectional study

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 133 (6)

BackgroundDeprescribing is a complex process requiring a patient-centred approach. One frequently expressed deprescribing barrier is patients' attitud......

Heroin metabolism in human blood and its impact for the design of an immunotherapeutic approach against heroin effects

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 133 (4)

Immunotherapeutic interventions that block drug effects by binding drug molecules to specific antibodies in the bloodstream have shown promising effec......

Does lithium poisoning induce brain injuries?-A histopathological rat study

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (5)

Due to a narrow therapeutic index, prolonged lithium treatment and overdose may result in neurotoxicity. Neurotoxicity is deemed reversible with lithi......

Bortezomib inhibits hepatocellular carcinoma via the Hippo-Yes-associated protein signalling pathway

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (4)

Hepatocellular carcinoma (HCC) is one of the principle causes of cancer-associated death throughout the world. However, the patients with HCC are inse......

Structure-activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (6)

The 57-mer full-length GPR15L(25-81) peptide has been identified as the principal endogenous agonist of the G protein-coupled receptor GPR15. Its main......

Deprescribing in a multimorbid older adult: A case vignette study among community pharmacists and primary care physicians

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 133 (6)

Collaborative deprescribing can include pharmacists' medication review with identification and suggestion of potential deprescribing targets to physic......

A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 133 (4)

Adhesion G protein-coupled receptors (GPCRs) are an underrepresented class of GPCRs in drug discovery. We previously developed an in vivo drug screeni......

Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (1)

Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated......

Vancomycin audit in the paediatric population: Patterns of use and appropriateness of therapeutic drug monitoring

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 132 (5)

AimsThis study aims to investigate prescribing and therapeutic drug monitoring (TDM) practices for vancomycin in paediatrics at the Jordan University ......

Inhibition of efflux transporters by poly ADP-ribose polymerase inhibitors

期刊: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2023; 133 (4)

Poly ADP-ribose polymerase (PARP) inhibitors have been approved for the treatment of various cancers. They share a similar mechanism of action but hav......

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