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Divergent Roles of Kupffer Cell TLR2/3 Signaling in Alcoholic Liver Disease and the Protective Role of EGCG

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 9 (1)

BACKGROUND & AIMS: Toll-like receptor 2 (TLR2) and TLR3 regulate hepatic immunity under pathological conditions, but their functions and potential......

Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 9 (1)

Asparaginase (ASNase) causes pancreatitis in approximately 10% of leukemia patients, and the mechanisms underlying this painful complication are not k......

Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 9 (4)

BACKGROUND & AIMS: Claudin-7 (Cldn7) is a tight junction (TJ) membrane protein located at the apical TJ and basolateral side of intestinal epithel......

Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 10 (1)

BACKGROUND & AIMS: In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 ......

Hypergastrinemia Expands Gastric ECL Cells Through CCK2R(+) Progenitor Cells via ERK Activation

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 10 (2)

Histidine decarboxylase & ndash;positive enterochromaf fin-like (ECL) cells are part of the cholecystokinin 2 receptor (Cck2r) lineage under hyper......

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 10 (2)

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that is manifested clinically by an increase in hepatic triglyce......

Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 10 (2)

Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a ......

GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a beta 1-Integrin Pathway

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 10 (3)

BACKGROUND & AIMS: Transforming growth factor (TGF-beta)- induced activation of quiescent hepatic stellate cells (HSCs) and their transformation t......

LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2020; 10 (4)

BACKGROUND & AIMS: Gemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict t......

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