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New QSAR models to predict chromosome damaging potential based on the in vivo micronucleus test

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

A large number of computer-based prediction methods to determine the potential of chemicals to induce mutations at the gene level has been developed o......

Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

This study unveiled the early cellular and molecular events induced by 1,2-dimethylhydrazine (DMH) in the colon and liver and their implications on pr......

Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

Background: Although thousands of different chemicals have been identified in cigarette smoke, the characterization of their urinary metabolites still......

Assessment of occupational exposure to stainless steel welding fumes - A human biomonitoring study

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

The aim of the study was to determine the concentration of hexavalent and trivalent chromium, nickel, manganese, and iron in welding fumes (WFs) and t......

Effect of PFOA on DNA Methylation and Alternative Splicing in Mouse Liver

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant prevalent in the environment and implicated in damage to the liver leading to a fatty ......

Recent advances in understanding the mechanisms of PM2.5-mediated neurodegenerative diseases

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

PM2.5 particles are widely believed to be associated with respiratory and cardiovascular diseases. However, recent studies have reported that PM2.5 ma......

Single- and repeated-dose toxicity studies on the novel HIV maturation inhibitor QF-036 in Sprague-Dawley rats

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

QF-036 is a novel human immunodeficiency virus (HIV) maturation inhibitor that is a lupine triterpenoid derivative. The objective of this study was to......

Biomonitoring of the benzene metabolite s-phenylmercapturic acid and the toluene metabolite s-benzylmercapturic acid in urine from firefighters

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

The aim of this study was to determine firefighter's exposure to benzene and toluene during a fire drill by monitoring air benzene and toluene, and th......

Are pigs a suitable animal model for in vivo metabolism studies of new psychoactive substances? A comparison study using different in vitro/in vivo tools and U-47700 as model drug

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

Being highly potent, New Synthetic Opioids (NSO) have become a public health concern. Little is known though about the metabolism and toxicokinetics (......

Assessment of children's exposure to currently used pesticides in wallonia, Belgium

期刊: TOXICOLOGY LETTERS, 2020; 329 ()

In spring 2016, a study was carried out to characterize currently used pesticide (CUP) exposure among children living in Wallonia (Belgium). Pesticide......

Anticoagulant activity of black snake (Elapidae: Pseudechis ) venoms: Mechanisms, potency, and antivenom e fficacy

期刊: TOXICOLOGY LETTERS, 2020; 330 ()

Venoms from Pseudechis species (Australian black snakes) within the Elapidae family are rich in anticoagulant PLA 2 toxins, with the exception of one ......

E ffects of Ochratoxin A exposure on DNA damage in porcine granulosa cells in vitro

期刊: TOXICOLOGY LETTERS, 2020; 330 ()

Ochratoxin A (OTA), a feed mycotoxin, tends to impair the reproductive performance of animals. Our previous studies have demonstrated that OTA exposur......

Short-term perinatal toxicity study in sprague Dawley rats with the plasticizer and emerging contaminant N-Butylbenzenesulfonamide

期刊: TOXICOLOGY LETTERS, 2020; 330 ()

N-Butylbenzenesulfonamide (NBBS) is a plasticizer and emerging contaminant that has been detected in a wide array of environmental samples. There are ......

Poly (ADP -Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids -induced nephrotoxicity in cholestatic rats

期刊: TOXICOLOGY LETTERS, 2020; 330 ()

Cholestatic liver disease is a clinical complication with a wide range of etiologies. The liver is the primary organ influenced by cholestasis. Other ......

High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis

期刊: TOXICOLOGY LETTERS, 2020; 330 ()

Silicosis is an inflammatory and fibrotic lung disease caused by prolonged inhalation of silica. The potential role of high-mobility group box-1 (HMGB......

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